Lopez MA, Andreasi Bassi M, Confalone L, Silvestre F, Arcuri C The treatment of peri-implant diseases: a new approach using hybenx(®) as a decontaminant for implant surface and oral tissues. Oral Implantol (Rome). 2016 Nov 13;9(3):106-114. doi: 10.11138/orl/2016.9.3.106. eCollection 2016 Jul-Sep.
Magnusson B Therapeutic pulpotomy in primary molars--clinical and histological follow-up. II. Zinc oxide-eugenol as wound dressing. Odontol Revy. 1971;22(1):45-54.
Pini-Prato G, Magnani C, Rotundo R Nonsurgical Treatment of Peri-implantitis Using the Biofilm Decontamination Approach: A Case Report Study. Int J Periodontics Restorative Dent. 2016 May-Jun;36(3):383-91. doi: 10.11607/prd.2653.
Pini-Prato G, Magnani C, Rotundo R Treatment of Acute Periodontal Abscesses Using the Biofilm Decontamination Approach: A Case Report Study. Int J Periodontics Restorative Dent. 2016 Jan-Feb;36(1):55-63. doi: 10.11607/prd.2557.
Porter SR, Al-Johani K, Fedele S, Moles DR Randomised controlled trial of the efficacy of HybenX in the symptomatic treatment of recurrent aphthous stomatitis. Oral Dis. 2009 Mar;15(2):155-61. doi: 10.1111/j.1601-0825.2008.01503.x.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
