Endosseous Dental Implant Failure — A Clinical Trial of Dental Implants in Titanium-zirconium Alloy
Citation(s)
Barter S, Stone P, Brägger U A pilot study to evaluate the success and survival rate of titanium-zirconium implants in partially edentulous patients: results after 24 months of follow-up. Clin Oral Implants Res. 2012 Jul;23(7):873-81. doi: 10.1111/j.1600-0501.2011.02231.x. Epub 2011 Jun 24.
Benic GI, Gallucci GO, Mokti M, Hämmerle CH, Weber HP, Jung RE Titanium-zirconium narrow-diameter versus titanium regular-diameter implants for anterior and premolar single crowns: 1-year results of a randomized controlled clinical study. J Clin Periodontol. 2013 Nov;40(11):1052-61. doi: 10.1111/jcpe.12156. Epub 2013 Sep 8.
Chrcanovic BR, Albrektsson T, Wennerberg A Smoking and dental implants: A systematic review and meta-analysis. J Dent. 2015 May;43(5):487-98. doi: 10.1016/j.jdent.2015.03.003. Epub 2015 Mar 14. Review.
Ekelund JA, Lindquist LW, Carlsson GE, Jemt T Implant treatment in the edentulous mandible: a prospective study on Brånemark system implants over more than 20 years. Int J Prosthodont. 2003 Nov-Dec;16(6):602-8.
Gottlow J, Dard M, Kjellson F, Obrecht M, Sennerby L Evaluation of a new titanium-zirconium dental implant: a biomechanical and histological comparative study in the mini pig. Clin Implant Dent Relat Res. 2012 Aug;14(4):538-45. doi: 10.1111/j.1708-8208.2010.00289.x. Epub 2010 Jun 25.
Hermann JS, Cochran DL, Nummikoski PV, Buser D Crestal bone changes around titanium implants. A radiographic evaluation of unloaded nonsubmerged and submerged implants in the canine mandible. J Periodontol. 1997 Nov;68(11):1117-30.
Jemt T, Ahlberg G, Henriksson K, Bondevik O Changes of anterior clinical crown height in patients provided with single-implant restorations after more than 15 years of follow-up. Int J Prosthodont. 2006 Sep-Oct;19(5):455-61.
Jemt T Single implants in the anterior maxilla after 15 years of follow-up: comparison with central implants in the edentulous maxilla. Int J Prosthodont. 2008 Sep-Oct;21(5):400-8.
Weber HP, Buser D, Fiorellini JP, Williams RC Radiographic evaluation of crestal bone levels adjacent to nonsubmerged titanium implants. Clin Oral Implants Res. 1992 Dec;3(4):181-8.
Wen B, Zhu F, Li Z, Zhang P, Lin X, Dard M The osseointegration behavior of titanium-zirconium implants in ovariectomized rabbits. Clin Oral Implants Res. 2014 Jul;25(7):819-25. doi: 10.1111/clr.12141. Epub 2013 Feb 21.
Wennerberg A, Albrektsson T, Andersson B Bone tissue response to commercially pure titanium implants blasted with fine and coarse particles of aluminum oxide. Int J Oral Maxillofac Implants. 1996 Jan-Feb;11(1):38-45.
Wennerberg A, Albrektsson T, Johansson C, Andersson B Experimental study of turned and grit-blasted screw-shaped implants with special emphasis on effects of blasting material and surface topography. Biomaterials. 1996 Jan;17(1):15-22.
Wennerberg A, Albrektsson T, Lausmaa J Torque and histomorphometric evaluation of c.p. titanium screws blasted with 25- and 75-microns-sized particles of Al2O3. J Biomed Mater Res. 1996 Feb;30(2):251-60.
A Randomized Controlled Clinical Trial of Dental Implants in Titanium-zirconium Alloy
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.