NCT02463630 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Abumi K, Takada T, Shono Y, Kaneda K, Fujiya M
Posterior occipitocervical reconstruction using cervical pedicle screws and plate-rod systems. Spine (Phila Pa 1976). 1999 Jul 15;24(14):1425-34.
Behari S, Kalra SK, Kiran Kumar MV, Salunke P, Jaiswal AK, Jain VK
Chiari I malformation associated with atlanto-axial dislocation: focussing on the anterior cervico-medullary compression. Acta Neurochir (Wien). 2007 Jan;149(1):41-50; discussion 50. Epub
Goel A
Treatment of basilar invagination by atlantoaxial joint distraction and direct lateral mass fixation. J Neurosurg Spine. 2004 Oct;1(3):281-6.
Jian FZ, Chen Z, Wrede KH, Samii M, Ling F
Direct posterior reduction and fixation for the treatment of basilar invagination with atlantoaxial dislocation. Neurosurgery. 2010 Apr;66(4):678-87; discussion 687. doi: 10.1227/01.NEU.0000367632.45384.5A.
Wang C, Yan M, Zhou HT, Wang SL, Dang GT
Open reduction of irreducible atlantoaxial dislocation by transoral anterior atlantoaxial release and posterior internal fixation. Spine (Phila Pa 1976). 2006 May 15;31(11):E306-13.

Posterior Compression - Distraction Reduction (CDR) Technique in the Treatment of Basilar Invagination Associated With Atlantoaxial Dislocation

Clinical trial NCT02463630 - References