NCT00755365 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Agolini SF, Shah K, Jaffe J, Newcomb J, Rhodes M, Reed JF 3rd
Arterial embolization is a rapid and effective technique for controlling pelvic fracture hemorrhage. J Trauma. 1997 Sep;43(3):395-9.
Balogh Z, Caldwell E, Heetveld M, D'Amours S, Schlaphoff G, Harris I, Sugrue M
Institutional practice guidelines on management of pelvic fracture-related hemodynamic instability: do they make a difference? J Trauma. 2005 Apr;58(4):778-82.
Balogh Z, King KL, Mackay P, McDougall D, Mackenzie S, Evans JA, Lyons T, Deane SA
The epidemiology of pelvic ring fractures: a population-based study. J Trauma. 2007 Nov;63(5):1066-73; discussion 1072-3.
Bassam D, Cephas GA, Ferguson KA, Beard LN, Young JS
A protocol for the initial management of unstable pelvic fractures. Am Surg. 1998 Sep;64(9):862-7.
Fangio P, Asehnoune K, Edouard A, Smail N, Benhamou D
Early embolization and vasopressor administration for management of life-threatening hemorrhage from pelvic fracture. J Trauma. 2005 May;58(5):978-84; discussion 984.
Miller PR, Moore PS, Mansell E, Meredith JW, Chang MC
External fixation or arteriogram in bleeding pelvic fracture: initial therapy guided by markers of arterial hemorrhage. J Trauma. 2003 Mar;54(3):437-43.
Sadri H, Nguyen-Tang T, Stern R, Hoffmeyer P, Peter R
Control of severe hemorrhage using C-clamp and arterial embolization in hemodynamically unstable patients with pelvic ring disruption. Arch Orthop Trauma Surg. 2005 Sep;125(7):443-7.

Intraoperative Angioembolization in the Management of Pelvic Fracture-Related Hemodynamic Instability

Clinical trial NCT00755365 - References