Chung F, Elsaid H Screening for obstructive sleep apnea before surgery: why is it important? Curr Opin Anaesthesiol. 2009 Jun;22(3):405-11. doi: 10.1097/ACO.0b013e32832a96e2. Review.
Chung F, Liao P, Elsaid H, Islam S, Shapiro CM, Sun Y Oxygen desaturation index from nocturnal oximetry: a sensitive and specific tool to detect sleep-disordered breathing in surgical patients. Anesth Analg. 2012 May;114(5):993-1000. doi: 10.1213/ANE.0b013e318248f4f5. Epub 2012 Feb 24.
Chung F, Liao P, Yegneswaran B, Shapiro CM, Kang W Postoperative changes in sleep-disordered breathing and sleep architecture in patients with obstructive sleep apnea. Anesthesiology. 2014 Feb;120(2):287-98. doi: 10.1097/ALN.0000000000000040.
Gilmartin GS, Tamisier R, Curley M, Weiss JW Ventilatory, hemodynamic, sympathetic nervous system, and vascular reactivity changes after recurrent nocturnal sustained hypoxia in humans. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H778-85. doi: 10.1152/ajpheart.00653.2007. Epub 2008 Jun 6.
Gupta RM, Parvizi J, Hanssen AD, Gay PC Postoperative complications in patients with obstructive sleep apnea syndrome undergoing hip or knee replacement: a case-control study. Mayo Clin Proc. 2001 Sep;76(9):897-905.
Guralnick AS, Pant M, Minhaj M, Sweitzer BJ, Mokhlesi B CPAP adherence in patients with newly diagnosed obstructive sleep apnea prior to elective surgery. J Clin Sleep Med. 2012 Oct 15;8(5):501-6. doi: 10.5664/jcsm.2140.
Kehlet H, Rosenberg J Late post-operative hypoxaemia and organ dysfunction. Eur J Anaesthesiol Suppl. 1995 May;10:31-4.
Kohler M, Smith D, Tippett V, Stradling JR Predictors of long-term compliance with continuous positive airway pressure. Thorax. 2010 Sep;65(9):829-32. doi: 10.1136/thx.2010.135848.
Marin JM, Carrizo SJ, Vicente E, Agusti AG Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005 Mar 19-25;365(9464):1046-53.
Mehta V, Subramanyam R, Shapiro CM, Chung F Health effects of identifying patients with undiagnosed obstructive sleep apnea in the preoperative clinic: a follow-up study. Can J Anaesth. 2012 Jun;59(6):544-55. doi: 10.1007/s12630-012-9694-8. Epub 2012 Mar 30.
Mokhlesi B Empiric postoperative autotitrating positive airway pressure therapy: generating evidence in the perioperative care of patients at risk for obstructive sleep apnea. Chest. 2013 Jul;144(1):5-7. doi: 10.1378/chest.13-0017.
Nishino T, Shirahata M, Yonezawa T, Honda Y Comparison of changes in the hypoglossal and the phrenic nerve activity in response to increasing depth of anesthesia in cats. Anesthesiology. 1984 Jan;60(1):19-24.
O'Gorman SM, Gay PC, Morgenthaler TI Does autotitrating positive airway pressure therapy improve postoperative outcome in patients at risk for obstructive sleep apnea syndrome? A randomized controlled clinical trial. Chest. 2013 Jul;144(1):72-78. doi: 10.1378/chest.12-0989.
Parish JM, Somers VK Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc. 2004 Aug;79(8):1036-46. Review.
Ramakant Sharma ISB CPAP for Obstructive Sleep Apnea in the Post-Operative Setting: An Oximetry Evaluation Study. J Sleep Disord Ther 2013;02.
Reeves-Hoche MK, Meck R, Zwillich CW Nasal CPAP: an objective evaluation of patient compliance. Am J Respir Crit Care Med. 1994 Jan;149(1):149-54.
Sollevi A, Lindahl SG Hypoxic and hypercapnic ventilatory responses during isoflurane sedation and anaesthesia in women. Acta Anaesthesiol Scand. 1995 Oct;39(7):931-8.
Young T, Peppard PE, Gottlieb DJ Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39. Review.
The Association of CPAP Compliance and Nocturnal Hypoxemia in the Perioperative Period
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
