NCT02034370 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Fu ES, Downs JB, Schweiger JW, Miguel RV, Smith RA
Supplemental oxygen impairs detection of hypoventilation by pulse oximetry. Chest. 2004 Nov;126(5):1552-8.
Ramachandran SK, Kheterpal S, Consens F, Shanks A, Doherty TM, Morris M, Tremper KK
Derivation and validation of a simple perioperative sleep apnea prediction score. Anesth Analg. 2010 Apr 1;110(4):1007-15. doi: 10.1213/ANE.0b013e3181d489b0.
Tobias JD, Del Campo L, Kenter K, Groeper K, Gray B, Edwards J
Changes in transcutaneous carbon dioxide, oxygen saturation, and respiratory rate after interscalene block. South Med J. 2004 Jan;97(1):21-4.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S
The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993 Apr 29;328(17):1230-5.

Influence of Inter-scalene Blockade on Postoperative Episodic Desaturation in Patients at High Risk of Obstructive Sleep Apnea (OSA)

Clinical trial NCT02034370 - References