Brietzke SE, Mair EA Injection snoreplasty: extended follow-up and new objective data. Otolaryngol Head Neck Surg. 2003 May;128(5):605-15.
Brietzke SE, Mair EA Injection snoreplasty: how to treat snoring without all the pain and expense. Otolaryngol Head Neck Surg. 2001 May;124(5):503-10.
Chung F, Elsaid H Screening for obstructive sleep apnea before surgery: why is it important? Curr Opin Anaesthesiol. 2009 Jun;22(3):405-11. doi: 10.1097/ACO.0b013e32832a96e2. Review.
Collop NA Portable monitoring for the diagnosis of obstructive sleep apnea. Curr Opin Pulm Med. 2008 Nov;14(6):525-9. doi: 10.1097/MCP.0b013e328312ed4a. Review.
Drazen JM Sleep apnea syndrome. N Engl J Med. 2002 Feb 7;346(6):390.
Friedman M, Ibrahim H, Joseph NJ Staging of obstructive sleep apnea/hypopnea syndrome: a guide to appropriate treatment. Laryngoscope. 2004 Mar;114(3):454-9.
Guimarães KC, Drager LF, Genta PR, Marcondes BF, Lorenzi-Filho G Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2009 May 15;179(10):962-6. doi: 10.1164/rccm.200806-981OC. Epub 2009 Feb 20.
Guimarães KCC Efeitos dos exercícios orofaríngeos em pacientes com apnéia obstrutiva do sono moderada: estudo controlado e randomizado [Internet] [text]. Universidade de São Paulo; 2008. At: http://www.teses.usp.br/teses/disponiveis/5/5150/tde-22082008-170703/
Lorenzetti FTM Injeção roncoplástica: comparação entre etanol 50% e oleato de etanolamina 5% no tratamento do ronco [Internet] [text]. Universidade de São Paulo; 2011. At http://www.teses.usp.br/teses/disponiveis/5/5143/tde-20072011-151743/
Marshall NS, Wong KK, Cullen SR, Knuiman MW, Grunstein RR Snoring is not associated with all-cause mortality, incident cardiovascular disease, or stroke in the Busselton Health Study. Sleep. 2012 Sep 1;35(9):1235-40. doi: 10.5665/sleep.2076.
Nordgård S, Stene BK, Skjøstad KW Soft palate implants for the treatment of mild to moderate obstructive sleep apnea. Otolaryngol Head Neck Surg. 2006 Apr;134(4):565-70.
Norton PG, Dunn EV Snoring as a risk factor for disease: an epidemiological survey. Br Med J (Clin Res Ed). 1985 Sep 7;291(6496):630-2.
Phillipson EA Sleep apnea--a major public health problem. N Engl J Med. 1993 Apr 29;328(17):1271-3.
Sher AE, Schechtman KB, Piccirillo JF The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome. Sleep. 1996 Feb;19(2):156-77. Review.
Siegel JM Sleep viewed as a state of adaptive inactivity. Nat Rev Neurosci. 2009 Oct;10(10):747-53. doi: 10.1038/nrn2697. Epub 2009 Aug 5.
Young T, Peppard PE, Gottlieb DJ Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.