Clinical trial NCT04802044 - References

Obesity — COVID-19, Aging, and Cardiometabolic Risk Factors Study

Citation(s)

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  Obesity, the most common comorbidity in SARS-CoV-2: is leptin the link? Int J Obes (Lond). 2020 Sep;44(9):1810-1817. doi: 10.1038/s41366-020-0640-5. Epub 2020 Jul 9. Review.
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  Upregulation of angiotensin converting enzyme 2 by shear stress reduced inflammation and proliferation in vascular endothelial cells. Biochem Biophys Res Commun. 2020 May 7;525(3):812-818. doi: 10.1016/j.bbrc.2020.02.151. Epub 2020 Mar 10.
•   Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL; HCA Lung Biological Network
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  Obesity, Inflammation and Endothelial Dysfunction. J Chem Inf Model. 2019;53(9):1689-99.
•   van de Berg PJ, Griffiths SJ, Yong SL, Macaulay R, Bemelman FJ, Jackson S, Henson SM, ten Berge IJ, Akbar AN, van Lier RA
  Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol. 2010 Apr 1;184(7):3417-23. doi: 10.4049/jimmunol.0903442. Epub 2010 Feb 22.
•   van Deursen JM
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•   Wu H, Ballantyne CM
  Metabolic Inflammation and Insulin Resistance in Obesity. Circ Res. 2020 May 22;126(11):1549-1564. doi: 10.1161/CIRCRESAHA.119.315896. Epub 2020 May 21. Review.

COVID-19, Aging, and Cardiometabolic Risk Factors (CARAMEL) Study: Integrating Aging, Cardiovascular, Metabolic, and Immunological Studies to Unravel COVID-19 Pathophysiology

Details for clinical trial NCT04802044