Obesity — Reducing Obesity and Cartilage Compression in Knees
Citation(s)
Abu-Abeid S, Wishnitzer N, Szold A, Liebergall M, Manor O The influence of surgically-induced weight loss on the knee joint. Obes Surg. 2005 Nov-Dec;15(10):1437-42. doi: 10.1381/096089205774859281. Erratum In: Obes Surg. 2006 Apr;16(4):530. Manor, Orly [added].
Aspden RM Obesity punches above its weight in osteoarthritis. Nat Rev Rheumatol. 2011 Jan;7(1):65-8. doi: 10.1038/nrrheum.2010.123. Epub 2010 Aug 17.
Browning RC, Kram R Effects of obesity on the biomechanics of walking at different speeds. Med Sci Sports Exerc. 2007 Sep;39(9):1632-41. doi: 10.1249/mss.0b013e318076b54b.
Carman WJ, Sowers M, Hawthorne VM, Weissfeld LA Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am J Epidemiol. 1994 Jan 15;139(2):119-29. doi: 10.1093/oxfordjournals.aje.a116974.
Englund M, Lohmander LS Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum. 2004 Sep;50(9):2811-9. doi: 10.1002/art.20489.
Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med. 1992 Apr 1;116(7):535-9. doi: 10.7326/0003-4819-116-7-535.
Felson DT Does excess weight cause osteoarthritis and, if so, why? Ann Rheum Dis. 1996 Sep;55(9):668-70. doi: 10.1136/ard.55.9.668. No abstract available.
Felson DT Relation of obesity and of vocational and avocational risk factors to osteoarthritis. J Rheumatol. 2005 Jun;32(6):1133-5. No abstract available.
Felson DT Weight and osteoarthritis. Am J Clin Nutr. 1996 Mar;63(3 Suppl):430S-432S. doi: 10.1093/ajcn/63.3.430.
Goldring SR, Goldring MB Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other? Arthritis Res Ther. 2010;12(5):143. doi: 10.1186/ar3135. Epub 2010 Oct 19.
Griffin TM, Guilak F Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. 2008;45(3-4):387-98.
Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord. 2008 Oct 2;9:132. doi: 10.1186/1471-2474-9-132.
Messier SP, Gutekunst DJ, Davis C, DeVita P Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 2005 Jul;52(7):2026-32. doi: 10.1002/art.21139.
Pereira D, Peleteiro B, Araujo J, Branco J, Santos RA, Ramos E The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthritis Cartilage. 2011 Nov;19(11):1270-85. doi: 10.1016/j.joca.2011.08.009. Epub 2011 Aug 24.
Powell A, Teichtahl AJ, Wluka AE, Cicuttini FM Obesity: a preventable risk factor for large joint osteoarthritis which may act through biomechanical factors. Br J Sports Med. 2005 Jan;39(1):4-5. doi: 10.1136/bjsm.2004.011841.
Ringdahl E, Pandit S Treatment of knee osteoarthritis. Am Fam Physician. 2011 Jun 1;83(11):1287-92.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.