Bird SR, Hawley JA Update on the effects of physical activity on insulin sensitivity in humans. BMJ Open Sport Exerc Med. 2017 Mar 1;2(1):e000143. doi: 10.1136/bmjsem-2016-000143. eCollection 2016.
BROZEK J, GRANDE F, ANDERSON JT, KEYS A DENSITOMETRIC ANALYSIS OF BODY COMPOSITION: REVISION OF SOME QUANTITATIVE ASSUMPTIONS. Ann N Y Acad Sci. 1963 Sep 26;110:113-40. doi: 10.1111/j.1749-6632.1963.tb17079.x. No abstract available.
DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes. 1981 Dec;30(12):1000-7. doi: 10.2337/diab.30.12.1000. No abstract available.
Di Meo S, Iossa S, Venditti P Skeletal muscle insulin resistance: role of mitochondria and other ROS sources. J Endocrinol. 2017 Apr;233(1):R15-R42. doi: 10.1530/JOE-16-0598.
Felber JP, Golay A Pathways from obesity to diabetes. Int J Obes Relat Metab Disord. 2002 Sep;26 Suppl 2:S39-45. doi: 10.1038/sj.ijo.0802126.
Gibala MJ, Gillen JB, Percival ME Physiological and health-related adaptations to low-volume interval training: influences of nutrition and sex. Sports Med. 2014 Nov;44 Suppl 2(Suppl 2):S127-37. doi: 10.1007/s40279-014-0259-6.
Godkin FE, Jenkins EM, Little JP, Nazarali Z, Percival ME, Gibala MJ The effect of brief intermittent stair climbing on glycemic control in people with type 2 diabetes: a pilot study. Appl Physiol Nutr Metab. 2018 Sep;43(9):969-972. doi: 10.1139/apnm-2018-0135. Epub 2018 May 2.
Henriksen EJ Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol (1985). 2002 Aug;93(2):788-96. doi: 10.1152/japplphysiol.01219.2001.
Honda H, Igaki M, Hatanaka Y, Komatsu M, Tanaka S, Miki T, Suzuki T, Takaishi T, Hayashi T Stair climbing/descending exercise for a short time decreases blood glucose levels after a meal in people with type 2 diabetes. BMJ Open Diabetes Res Care. 2016 Jul 25;4(1):e000232. doi: 10.1136/bmjdrc-2016-000232. eCollection 2016. Erratum In: BMJ Open Diabetes Res Care. 2016; 4(1): e000232corr1. BMJ Open Diabetes Res Care. 2016;4(1):e000232corr1.
Hossain P, Kawar B, El Nahas M Obesity and diabetes in the developing world--a growing challenge. N Engl J Med. 2007 Jan 18;356(3):213-5. doi: 10.1056/NEJMp068177. No abstract available. Erratum In: N Engl J Med. 2007 Mar 1;356(9):973.
Keshel TE, Coker RH Exercise Training and Insulin Resistance: A Current Review. J Obes Weight Loss Ther. 2015 Jul;5(Suppl 5):S5-003. doi: 10.4172/2165-7904.S5-003. Epub 2015 Jul 30.
Kong Z, Fan X, Sun S, Song L, Shi Q, Nie J Comparison of High-Intensity Interval Training and Moderate-to-Vigorous Continuous Training for Cardiometabolic Health and Exercise Enjoyment in Obese Young Women: A Randomized Controlled Trial. PLoS One. 2016 Jul 1;11(7):e0158589. doi: 10.1371/journal.pone.0158589. eCollection 2016.
Korkiakangas EE, Alahuhta MA, Laitinen JH Barriers to regular exercise among adults at high risk or diagnosed with type 2 diabetes: a systematic review. Health Promot Int. 2009 Dec;24(4):416-27. doi: 10.1093/heapro/dap031. Epub 2009 Sep 30.
Shaw JE, Sicree RA, Zimmet PZ Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010 Jan;87(1):4-14. doi: 10.1016/j.diabres.2009.10.007. Epub 2009 Nov 6.
Sherwood NE, Jeffery RW The behavioral determinants of exercise: implications for physical activity interventions. Annu Rev Nutr. 2000;20:21-44. doi: 10.1146/annurev.nutr.20.1.21.
Takaishi T, Imaeda K, Tanaka T, Moritani T, Hayashi T A short bout of stair climbing-descending exercise attenuates postprandial hyperglycemia in middle-aged males with impaired glucose tolerance. Appl Physiol Nutr Metab. 2012 Feb;37(1):193-6. doi: 10.1139/h11-140. Epub 2011 Dec 23.
Thompson PD, Arena R, Riebe D, Pescatello LS; American College of Sports Medicine ACSM's new preparticipation health screening recommendations from ACSM's guidelines for exercise testing and prescription, ninth edition. Curr Sports Med Rep. 2013 Jul-Aug;12(4):215-7. doi: 10.1249/JSR.0b013e31829a68cf. No abstract available.
Wilmore JH A simplified method for determination of residual lung volumes. J Appl Physiol. 1969 Jul;27(1):96-100. doi: 10.1152/jappl.1969.27.1.96. No abstract available.
Zhang L, Feng Y, List J, Kasichayanula S, Pfister M Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab. 2010 Jun;12(6):510-6. doi: 10.1111/j.1463-1326.2010.01216.x.
Zierath JR, Krook A, Wallberg-Henriksson H Insulin action and insulin resistance in human skeletal muscle. Diabetologia. 2000 Jul;43(7):821-35. doi: 10.1007/s001250051457. No abstract available.
A HIIT to Improve Metabolic Health in Obese Adults With Insulin Resistance
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.