Obesity — DIETFITS Study (Diet Intervention Examining the Factors Interacting With Treatment Success
Citation(s)
Fielding-Singh P, Patel ML, King AC, Gardner CD Baseline Psychosocial and Demographic Factors Associated with Study Attrition and 12-Month Weight Gain in the DIETFITS Trial. Obesity (Silver Spring). 2019 Dec;27(12):1997-2004. doi: 10.1002/oby.22650. Epub 2019 Oct 21.
Gardner CD, Trepanowski JF, Del Gobbo LC, Hauser ME, Rigdon J, Ioannidis JPA, Desai M, King AC Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial. JAMA. 2018 Feb 20;319(7):667-679. doi: 10.1001/jama.2018.0245. Erratum In: JAMA. 2018 Apr 3;319(13):1386. JAMA. 2018 Apr 24;319(16):1728.
Grembi JA, Nguyen LH, Haggerty TD, Gardner CD, Holmes SP, Parsonnet J Gut microbiota plasticity is correlated with sustained weight loss on a low-carb or low-fat dietary intervention. Sci Rep. 2020 Jan 29;10(1):1405. doi: 10.1038/s41598-020-58000-y. Erratum In: Sci Rep. 2020 Jul 1;10(1):11095.
Mummah SA, King AC, Gardner CD, Sutton S Iterative development of Vegethon: a theory-based mobile app intervention to increase vegetable consumption. Int J Behav Nutr Phys Act. 2016 Aug 8;13:90. doi: 10.1186/s12966-016-0400-z.
Mummah SA, Mathur M, King AC, Gardner CD, Sutton S Mobile Technology for Vegetable Consumption: A Randomized Controlled Pilot Study in Overweight Adults. JMIR Mhealth Uhealth. 2016 May 18;4(2):e51. doi: 10.2196/mhealth.5146.
Mummah SA, Robinson TN, King AC, Gardner CD, Sutton S IDEAS (Integrate, Design, Assess, and Share): A Framework and Toolkit of Strategies for the Development of More Effective Digital Interventions to Change Health Behavior. J Med Internet Res. 2016 Dec 16;18(12):e317. doi: 10.2196/jmir.5927.
Shih CW, Hauser ME, Aronica L, Rigdon J, Gardner CD Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial. Am J Clin Nutr. 2019 Feb 1;109(2):433-441. doi: 10.1093/ajcn/nqy305. Erratum In: Am J Clin Nutr. 2020 Feb 1;111(2):490.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
