Obesity — Exercise Adherence in a Behavioral Weight Loss Program
Citation(s)
Dunn AL, Andersen RE, Jakicic JM Lifestyle physical activity interventions. History, short- and long-term effects, and recommendations. Am J Prev Med. 1998 Nov;15(4):398-412. Review.
Jakicic JM, Lang W, Wing RR Do African-American and Caucasian overweight women differ in oxygen consumption during fixed periods of exercise? Int J Obes Relat Metab Disord. 2001 Jul;25(7):949-53.
Jakicic JM, Wing RR, Winters-Hart C Relationship of physical activity to eating behaviors and weight loss in women. Med Sci Sports Exerc. 2002 Oct;34(10):1653-9.
Jakicic JM, Winters C, Lang W, Wing RR Effects of intermittent exercise and use of home exercise equipment on adherence, weight loss, and fitness in overweight women: a randomized trial. JAMA. 1999 Oct 27;282(16):1554-60.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
