Almasy L Introduction: methods for detecting genotype X environment interaction. . Genet Epidemiol. 2001;21 Suppl 1:S817-8.
Arya R, Duggirala R, Williams JT, Almasy L, Blangero J Power to localize the major gene for disease liability is increased after accounting for the effects of related quantitative phenotypes. Genet Epidemiol. 2001;21 Suppl 1:S774-8.
Blangero J, Williams-Blangero S, Mahaney MC Multivariate genetic analysis of apo AI concentration and HDL subfractions: evidence for major locus pleiotropy. Genet Epidemiol. 1993;10(6):617-22.
Blangero J Genetic analysis of a common oligogenic trait with quantitative correlates: summary of GAW9 results. Genet Epidemiol. 1995;12(6):689-706.
Blangero J Localization and identification of human quantitative trait loci: king harvest has surely come. Curr Opin Genet Dev. 2004 Jun;14(3):233-40. Review.
Blangero J Statistical genetic approaches to human adaptability. Hum Biol. 1993 Dec;65(6):941-66.
Cole SA, Hixson JE PCR methodology applied to genetic studies of lipoprotein metabolism and atherosclerosis. Methods Mol Biol. 1998;110:1-34. Review.
Göring HH, Terwilliger JD, Blangero J Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet. 2001 Dec;69(6):1357-69. Epub 2001 Oct 9.
Göring HH, Williams JT, Blangero J Linkage analysis of quantitative traits in randomly ascertained pedigrees: comparison of penetrance-based and variance component analysis. Genet Epidemiol. 2001;21 Suppl 1:S783-8.
Hsueh WC, Göring HH, Blangero J, Mitchell BD Replication of linkage to quantitative trait loci: variation in location and magnitude of the lod score. Genet Epidemiol. 2001;21 Suppl 1:S473-8.
Kammerer CM, VandeBerg JL, Haffner SM, Hixson JE Apolipoprotein B (apo B) signal peptide length polymorphisms are associated with apo B, low density lipoprotein cholesterol, and glucose levels in Mexican Americans. Atherosclerosis. 1996 Feb;120(1-2):37-45.
MacCluer JW, Blangero J, Dyer TD, Kammerer CM Simulation of a common oligogenic disease with quantitative risk factors. GAW9 problem 2: the answers. Genet Epidemiol. 1995;12(6):707-12.
MacCluer JW, Blangero J, Dyer TD, Speer MC GAW10: simulated family data for a common oligogenic disease with quantitative risk factors. Genet Epidemiol. 1997;14(6):737-42.
Mahaney MC, Jaquish CE, Comuzzie AG Statistical genetics of normal variation in family data for oligogenic diseases. Genet Epidemiol. 1995;12(6):783-7.
Rainwater DL, Haffner SM Insulin and 2-hour glucose levels are inversely related to Lp(a) concentrations controlled for LPA genotype. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1335-41.
Rainwater DL, Kammerer CM, VandeBerg JL, Hixson JE Characterization of the genetic elements controlling lipoprotein(a) concentrations in Mexican Americans. Evidence for at least three controlling elements linked to LPA, the locus encoding apolipoprotein(a). Atherosclerosis. 1997 Feb 10;128(2):223-33.
Rainwater DL, Kammerer CM Lipoprotein Lp(a): effects of allelic variation at the LPA locus. J Exp Zool. 1998 Sep-Oct 1;282(1-2):54-61.
Rainwater DL Electrophoretic separation of LDL and HDL subclasses. Methods Mol Biol. 1998;110:137-51. Review.
Rainwater DL Genetic basis for multimodal relationship between apolipoprotein (a) size and lipoprotein (a) concentration in Mexican-Americans. Atherosclerosis. 1995 Jun;115(2):165-71.
Rainwater DL Lp(a) concentrations are related to plasma lipid concentrations. Atherosclerosis. 1996 Nov 15;127(1):13-8.
Williams JT, Blangero J Asymptotic power of likelihood-ratio tests for detecting quantitative trait loci using the COGA data. Genet Epidemiol. 1999;17 Suppl 1:S397-402.
Williams JT, Blangero J Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples. Genet Epidemiol. 1999;16(2):113-34.
Williams JT, Blangero J Power of variance component linkage analysis-II. Discrete traits. Ann Hum Genet. 2004 Nov;68(Pt 6):620-32.
Williams JT, Duggirala R, Blangero J Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees. Genet Epidemiol. 1997;14(6):1065-70.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
