Clinical trial NCT06279780 - References

Obesity Adult Onset — Gut Microbiota, Mitochondrial Function and Metabolic Health in Obesity

Citation(s)

•   Armitage EG, Rupérez FJ, Barbas C
  Metabolomics of diet-related diseases using mass spectrometry. Trends Analyt Chem. 2013; 52: 61-73.
•   Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE
  Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005 Feb;11(2):183-90. doi: 10.1038/nm1166. Epub 2005 Jan 30.
•   Chen HH, Tseng YJ, Wang SY, Tsai YS, Chang CS, Kuo TC, Yao WJ, Shieh CC, Wu CH, Kuo PH
  The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity. Int J Obes (Lond). 2015 Aug;39(8):1241-8. doi: 10.1038/ijo.2015.65. Epub 2015 Apr 24.
•   Esser N, L'homme L, De Roover A, Kohnen L, Scheen AJ, Moutschen M, Piette J, Legrand-Poels S, Paquot N
  Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue. Diabetologia. 2013 Nov;56(11):2487-97. doi: 10.1007/s00125-013-3023-9. Epub 2013 Sep 7.
•   Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH
  Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One. 2010 Dec 10;5(12):e15234. doi: 10.1371/journal.pone.0015234.
•   Fruhbeck G, Gomez-Ambrosi J
  Rationale for the existence of additional adipostatic hormones. FASEB J. 2001 Sep;15(11):1996-2006. doi: 10.1096/fj.00-0829hyp.
•   Gao X, Zhang W, Wang Y, Pedram P, Cahill F, Zhai G, Randell E, Gulliver W, Sun G
  Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals. Nutr Metab (Lond). 2016 May 12;13:33. doi: 10.1186/s12986-016-0095-9. eCollection 2016.
•   Gaye A, Doumatey AP, Davis SK, Rotimi CN, Gibbons GH
  Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans. NPJ Genom Med. 2018 Jan 29;3:4. doi: 10.1038/s41525-018-0043-x. eCollection 2018.
•   Gomez-Ambrosi J, Silva C, Galofre JC, Escalada J, Santos S, Millan D, Vila N, Ibanez P, Gil MJ, Valenti V, Rotellar F, Ramirez B, Salvador J, Fruhbeck G
  Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int J Obes (Lond). 2012 Feb;36(2):286-94. doi: 10.1038/ijo.2011.100. Epub 2011 May 17.
•   Gregor MF, Hotamisligil GS
  Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res. 2007 Sep;48(9):1905-14. doi: 10.1194/jlr.R700007-JLR200. Epub 2007 May 9.
•   Hotamisligil GS
  Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010 Mar 19;140(6):900-17. doi: 10.1016/j.cell.2010.02.034.
•   Hotamisligil GS
  Inflammation and metabolic disorders. Nature. 2006 Dec 14;444(7121):860-7. doi: 10.1038/nature05485.
•   Howard JK, Flier JS
  Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab. 2006 Nov;17(9):365-71. doi: 10.1016/j.tem.2006.09.007. Epub 2006 Sep 28.
•   Kogelman LJ, Fu J, Franke L, Greve JW, Hofker M, Rensen SS, Kadarmideen HN
  Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese Individuals. PLoS One. 2016 Dec 1;11(12):e0167519. doi: 10.1371/journal.pone.0167519. eCollection 2016.
•   Lagerros YT, Rossner S
  Obesity management: what brings success? Therap Adv Gastroenterol. 2013 Jan;6(1):77-88. doi: 10.1177/1756283X12459413.
•   Lebrun P, Van Obberghen E
  SOCS proteins causing trouble in insulin action. Acta Physiol (Oxf). 2008 Jan;192(1):29-36. doi: 10.1111/j.1748-1716.2007.01782.x.
•   Mangge H, Zelzer S, Puerstner P, Schnedl WJ, Reeves G, Postolache TT, Weghuber D
  Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults. Obesity (Silver Spring). 2013 Jan;21(1):E71-7. doi: 10.1002/oby.20061. Epub 2013 Jan 29.
•   Messier V, Karelis AD, Robillard ME, Bellefeuille P, Brochu M, Lavoie JM, Rabasa-Lhoret R
  Metabolically healthy but obese individuals: relationship with hepatic enzymes. Metabolism. 2010 Jan;59(1):20-4. doi: 10.1016/j.metabol.2009.06.020. Epub 2009 Aug 25.
•   Naukkarinen J, Heinonen S, Hakkarainen A, Lundbom J, Vuolteenaho K, Saarinen L, Hautaniemi S, Rodriguez A, Fruhbeck G, Pajunen P, Hyotylainen T, Oresic M, Moilanen E, Suomalainen A, Lundbom N, Kaprio J, Rissanen A, Pietilainen KH
  Characterising metabolically healthy obesity in weight-discordant monozygotic twins. Diabetologia. 2014 Jan;57(1):167-76. doi: 10.1007/s00125-013-3066-y. Epub 2013 Oct 8.
•   Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP
  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009 Apr;9(4):311-26. doi: 10.1016/j.cmet.2009.02.002. Erratum In: Cell Metab. 2009 Jun;9(6):565-6.
•   Olefsky JM, Glass CK
  Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219-46. doi: 10.1146/annurev-physiol-021909-135846.
•   Phillips CM
  Metabolically healthy obesity across the life course: epidemiology, determinants, and implications. Ann N Y Acad Sci. 2017 Mar;1391(1):85-100. doi: 10.1111/nyas.13230. Epub 2016 Oct 10.
•   Plourde G, Karelis AD
  Current issues in the identification and treatment of metabolically healthy but obese individuals. Nutr Metab Cardiovasc Dis. 2014 May;24(5):455-9. doi: 10.1016/j.numecd.2013.12.002. Epub 2014 Jan 12.
•   Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie ME, Messier V, Sladek R, Rabasa-Lhoret R
  Characterizing the profile of obese patients who are metabolically healthy. Int J Obes (Lond). 2011 Jul;35(7):971-81. doi: 10.1038/ijo.2010.216. Epub 2010 Oct 26.
•   Smith KB, Smith MS
  Obesity Statistics. Prim Care. 2016 Mar;43(1):121-35, ix. doi: 10.1016/j.pop.2015.10.001. Epub 2016 Jan 12.
•   Stefan N, Haring HU, Hu FB, Schulze MB
  Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol. 2013 Oct;1(2):152-62. doi: 10.1016/S2213-8587(13)70062-7. Epub 2013 Aug 30.
•   Suhre K, Meisinger C, Doring A, Altmaier E, Belcredi P, Gieger C, Chang D, Milburn MV, Gall WE, Weinberger KM, Mewes HW, Hrabe de Angelis M, Wichmann HE, Kronenberg F, Adamski J, Illig T
  Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One. 2010 Nov 11;5(11):e13953. doi: 10.1371/journal.pone.0013953.
•   Tchernof A, Despres JP
  Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011.
•   Velho S, Paccaud F, Waeber G, Vollenweider P, Marques-Vidal P
  Metabolically healthy obesity: different prevalences using different criteria. Eur J Clin Nutr. 2010 Oct;64(10):1043-51. doi: 10.1038/ejcn.2010.114. Epub 2010 Jul 14.
•   Westermann B
  Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol. 2010 Dec;11(12):872-84. doi: 10.1038/nrm3013.
•   Wiklund PK, Pekkala S, Autio R, Munukka E, Xu L, Saltevo J, Cheng S, Kujala UM, Alen M, Cheng S
  Serum metabolic profiles in overweight and obese women with and without metabolic syndrome. Diabetol Metab Syndr. 2014 Mar 20;6(1):40. doi: 10.1186/1758-5996-6-40.
•   Zorzano A, Claret M
  Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction. Front Aging Neurosci. 2015 Jun 10;7:101. doi: 10.3389/fnagi.2015.00101. eCollection 2015.

Effect of a Very Low-calorie Diet on Microbiota, Oxidative Stress, Inflammatory and Metabolomic Profile in Metabolically Healthy and Unhealthy Obese Subjects

Details for clinical trial NCT06279780