NCT03694015 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Chow E, Zeng L, Salvo N, Dennis K, Tsao M, Lutz S
Update on the systematic review of palliative radiotherapy trials for bone metastases. Clin Oncol (R Coll Radiol). 2012 Mar;24(2):112-24. doi: 10.1016/j.clon.2011.11.004. Epub 2011 Nov 29.
Guerrero Urbano MT, Nutting CM
Clinical use of intensity-modulated radiotherapy: part I. Br J Radiol. 2004 Feb;77(914):88-96. doi: 10.1259/bjr/84246820.
Lutz S, Berk L, Chang E, Chow E, Hahn C, Hoskin P, Howell D, Konski A, Kachnic L, Lo S, Sahgal A, Silverman L, von Gunten C, Mendel E, Vassil A, Bruner DW, Hartsell W; American Society for Radiation Oncology (ASTRO)
Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):965-76. doi: 10.1016/j.ijrobp.2010.11.026. Epub 2011 Jan 27.
Miles EA, Clark CH, Urbano MT, Bidmead M, Dearnaley DP, Harrington KJ, A'Hern R, Nutting CM
The impact of introducing intensity modulated radiotherapy into routine clinical practice. Radiother Oncol. 2005 Dec;77(3):241-6. doi: 10.1016/j.radonc.2005.10.011. Epub 2005 Nov 17.
Nielsen OS
Palliative radiotherapy of bone metastases: there is now evidence for the use of single fractions. Radiother Oncol. 1999 Aug;52(2):95-6. doi: 10.1016/s0167-8140(99)00109-7. No abstract available.
Teoh M, Clark CH, Wood K, Whitaker S, Nisbet A
Volumetric modulated arc therapy: a review of current literature and clinical use in practice. Br J Radiol. 2011 Nov;84(1007):967-96. doi: 10.1259/bjr/22373346.
Webb S
Advances in treatment with intensity-modulated conformal radiotherapy. Tumori. 1998 Mar-Apr;84(2):112-26. doi: 10.1177/030089169808400206.

SUPR-3D: A Randomized Phase III Trial Comparing Simple Unplanned Palliative Radiotherapy Versus 3D Conformal Radiotherapy for Patients With Bone Metastases

Details for clinical trial NCT03694015

Clinical trial NCT03694015 - References