Edmond K, Zaidi A New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS Med. 2010 Mar 9;7(3):e1000213. doi: 10.1371/journal.pmed.1000213.
H -Y. Wu, M. Rubinstein, E. Shih, J. Guttag, F. Durand, and W. T. Freeman. Eulerian video magnification for revealing subtle changes in the world. ACM Transactions on Graphics, 31(4), 2012.
J M. Kuller. Skin breakdown: risk factors, prevention and treatment. Newborn Infant Nurs, 1:35-42, 2001. [11] M. L. Neonatal innate immunity to infectious agents. Infection and Immunity, 74:19992006, 2006.
K J., B. S., G. G., and D. J. Non-contact heart rate and heart rate variability measurements. Biomedical signal processing and control, 13:102-112, 2014.
Poh MZ, McDuff DJ, Picard RW Non-contact, automated cardiac pulse measurements using video imaging and blind source separation. Opt Express. 2010 May 10;18(10):10762-74. doi: 10.1364/OE.18.010762.
Sullivan BA, Grice SM, Lake DE, Moorman JR, Fairchild KD Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants. J Pediatr. 2014 Apr;164(4):775-80. doi: 10.1016/j.jpeds.2013.11.038. Epub 2014 Jan 10.
Sztajzel J Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system. Swiss Med Wkly. 2004 Sep 4;134(35-36):514-22.
Wynn JL, Wong HR Pathophysiology and treatment of septic shock in neonates. Clin Perinatol. 2010 Jun;37(2):439-79. doi: 10.1016/j.clp.2010.04.002. Review.
Young Infants Clinical Signs Study Group Clinical signs that predict severe illness in children under age 2 months: a multicentre study. Lancet. 2008 Jan 12;371(9607):135-42. doi: 10.1016/S0140-6736(08)60106-3.
Noninvasive Monitoring and Diagnosis of Physiologic Disturbances in Term and Preterm Newborns Using Video Analysis Techniques
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.