Jessen M, Malm L Definition, prevalence and development of nasal obstruction. Allergy. 1997;52(40 Suppl):3-6. doi: 10.1111/j.1398-9995.1997.tb04876.x. No abstract available.
Khosh MM, Jen A, Honrado C, Pearlman SJ Nasal valve reconstruction: experience in 53 consecutive patients. Arch Facial Plast Surg. 2004 May-Jun;6(3):167-71. doi: 10.1001/archfaci.6.3.167.
Kimbell JS, Frank-Ito DO Mechanical Nasal Dilators for the Management of Nasal Obstruction. JAMA Facial Plast Surg. 2016 Sep 1;18(5):389-90. doi: 10.1001/jamafacial.2016.0656. No abstract available.
Kiyohara N, Badger C, Tjoa T, Wong B A Comparison of Over-the-Counter Mechanical Nasal Dilators: A Systematic Review. JAMA Facial Plast Surg. 2016 Sep 1;18(5):385-9. doi: 10.1001/jamafacial.2016.0291.
Picavet VA, Grietens J, Jorissen M, Hellings PW Rhinoplasty from a rhinologist's perspective: need for recognition of associated sinonasal conditions. Am J Rhinol Allergy. 2012 Nov-Dec;26(6):493-6. doi: 10.2500/ajra.2012.26.3816.
Raudenbush B Stenting the nasal airway for maximizing inspiratory airflow: internal Max-Air Nose Cones versus external Breathe Right strip. Am J Rhinol Allergy. 2011 Jul-Aug;25(4):249-51. doi: 10.2500/ajra.2011.25.3621.
Samaha M, Rassouli A Spreader graft placement in endonasal rhinoplasty: Technique and a review of 100 cases. Plast Surg (Oakv). 2015 Winter;23(4):252-4. doi: 10.4172/plastic-surgery.1000944.
Assessing Mechanical Nasal Obstruction, a Potential New Treatment Option.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
