Myopia — The Effects of Low Dose Atropine on Choroidal Thickness
Citation(s)
Chakraborty R, Read SA, Collins MJ Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics. Invest Ophthalmol Vis Sci. 2011 Jul 11;52(8):5121-9. doi: 10.1167/iovs.11-7364.
Chakraborty R, Read SA, Collins MJ Monocular myopic defocus and daily changes in axial length and choroidal thickness of human eyes. Exp Eye Res. 2012 Oct;103:47-54. doi: 10.1016/j.exer.2012.08.002. Epub 2012 Aug 16.
Chia A, Lu QS, Tan D Five-Year Clinical Trial on Atropine for the Treatment of Myopia 2: Myopia Control with Atropine 0.01% Eyedrops. Ophthalmology. 2016 Feb;123(2):391-9. doi: 10.1016/j.ophtha.2015.07.004. Epub 2015 Aug 11.
Gong Q, Janowski M, Luo M, Wei H, Chen B, Yang G, Liu L Efficacy and Adverse Effects of Atropine in Childhood Myopia: A Meta-analysis. JAMA Ophthalmol. 2017 Jun 1;135(6):624-630. doi: 10.1001/jamaophthalmol.2017.1091. Review.
Howlett MH, McFadden SA Form-deprivation myopia in the guinea pig (Cavia porcellus). Vision Res. 2006 Jan;46(1-2):267-83. Epub 2005 Aug 31.
Howlett MH, McFadden SA Spectacle lens compensation in the pigmented guinea pig. Vision Res. 2009 Jan;49(2):219-27. doi: 10.1016/j.visres.2008.10.008. Epub 2008 Dec 4.
Hung LF, Wallman J, Smith EL 3rd Vision-dependent changes in the choroidal thickness of macaque monkeys. Invest Ophthalmol Vis Sci. 2000 May;41(6):1259-69.
McAlinden C, Pesudovs K, Moore JE The development of an instrument to measure quality of vision: the Quality of Vision (QoV) questionnaire. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5537-45. doi: 10.1167/iovs.10-5341. Epub 2010 May 26.
Nickla DL, Totonelly K Choroidal thickness predicts ocular growth in normal chicks but not in eyes with experimentally altered growth. Clin Exp Optom. 2015 Nov;98(6):564-70. doi: 10.1111/cxo.12317.
North RV, Kelly ME A review of the uses and adverse effects of topical administration of atropine. Ophthalmic Physiol Opt. 1987;7(2):109-14. Review.
Pediatric Eye Disease Investigator Group A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children. Arch Ophthalmol. 2002 Mar;120(3):268-78.
Rahman W, Chen FK, Yeoh J, Patel P, Tufail A, Da Cruz L Repeatability of manual subfoveal choroidal thickness measurements in healthy subjects using the technique of enhanced depth imaging optical coherence tomography. Invest Ophthalmol Vis Sci. 2011 Apr 8;52(5):2267-71. doi: 10.1167/iovs.10-6024. Print 2011 Apr.
Read SA, Alonso-Caneiro D, Vincent SJ, Collins MJ Longitudinal changes in choroidal thickness and eye growth in childhood. Invest Ophthalmol Vis Sci. 2015 May;56(5):3103-12. doi: 10.1167/iovs.15-16446.
Siegwart JT Jr, Norton TT The susceptible period for deprivation-induced myopia in tree shrew. Vision Res. 1998 Nov;38(22):3505-15.
Tan CS, Ouyang Y, Ruiz H, Sadda SR Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):261-6. doi: 10.1167/iovs.11-8782.
Troilo D, Nickla DL, Wildsoet CF Choroidal thickness changes during altered eye growth and refractive state in a primate. Invest Ophthalmol Vis Sci. 2000 May;41(6):1249-58.
Wallman J, Winawer J Homeostasis of eye growth and the question of myopia. Neuron. 2004 Aug 19;43(4):447-68. Review. Erratum in: Neuron. 2012 Apr 12;74(1):207.
Woodman EC, Read SA, Collins MJ Axial length and choroidal thickness changes accompanying prolonged accommodation in myopes and emmetropes. Vision Res. 2012 Nov 1;72:34-41. doi: 10.1016/j.visres.2012.09.009. Epub 2012 Sep 24.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
