Hassoun PM The right ventricle in scleroderma (2013 Grover Conference Series). Pulm Circ. 2015 Mar;5(1):3-14. doi: 10.1086/679607. Review.
Jiang M, Pu J, Yao J, Xu J, He B An acromegaly-induced cardiomyopathy mimicking amyloidosis: (Manifestation of acromegaly-induced-cardiomyopathy). Int J Cardiol. 2016 Jul 15;215:60-1. doi: 10.1016/j.ijcard.2016.04.043. Epub 2016 Apr 13.
Jiang M, Wang Z, Su X, Gong X, Pu J, Wu L, Liu C, Yao Q, Kong L, Xu J, He B The Significance of Interstitial Fibrosis on Left Ventricular Function in Hypertensive versus Hypertrophic Cardiomyopathy. Sci Rep. 2018 Jul 3;8(1):9995. doi: 10.1038/s41598-018-27049-1. Erratum in: Sci Rep. 2018 Aug 10;8(1):12232.
Jiang M, Xu J, He B Diffuse Epicardial Involvement on Cardiac Magnetic Resonance Imaging. JAMA Cardiol. 2016 Oct 1;1(7):845-846. doi: 10.1001/jamacardio.2016.2557.
Wigley FM, Lima JA, Mayes M, McLain D, Chapin JL, Ward-Able C The prevalence of undiagnosed pulmonary arterial hypertension in subjects with connective tissue disease at the secondary health care level of community-based rheumatologists (the UNCOVER study). Arthritis Rheum. 2005 Jul;52(7):2125-32.
Wu LM, An DL, Yao QY, Ou YZ, Lu Q, Jiang M, Xu JR Hypertrophic cardiomyopathy and left ventricular hypertrophy in hypertensive heart disease with mildly reduced or preserved ejection fraction: insight from altered mechanics and native T1 mapping. Clin Radiol. 2017 Oct;72(10):835-843. doi: 10.1016/j.crad.2017.04.019. Epub 2017 May 25.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
