Multiple Sclerosis — Pilates+4MS: Pilates Intervention for Multiple Sclerosis
Citation(s)
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Kinnett-Hopkins D, Adamson B, Rougeau K, Motl RW People with MS are less physically active than healthy controls but as active as those with other chronic diseases: An updated meta-analysis. Mult Scler Relat Disord. 2017 Apr;13:38-43. doi: 10.1016/j.msard.2017.01.016. Epub 2017 Feb 1.
Lancaster GA Pilot and feasibility studies come of age! Pilot Feasibility Stud. 2015;1(1):1. doi: 10.1186/2055-5784-1-1. Epub 2015 Jan 12.
Learmonth YC, Dlugonski DD, Pilutti LA, Sandroff BM, Motl RW The reliability, precision and clinically meaningful change of walking assessments in multiple sclerosis. Mult Scler. 2013 Nov;19(13):1784-91. doi: 10.1177/1352458513483890. Epub 2013 Apr 15.
Learmonth YC, Paul L, McFadyen AK, Mattison P, Miller L Reliability and clinical significance of mobility and balance assessments in multiple sclerosis. Int J Rehabil Res. 2012 Mar;35(1):69-74. doi: 10.1097/MRR.0b013e328350b65f.
Marques KAP, Trindade CBB, Almeida MCV, Bento-Torres NVO Pilates for rehabilitation in patients with multiple sclerosis: A systematic review of effects on cognition, health-related physical fitness, general symptoms and quality of life. J Bodyw Mov Ther. 2020 Apr;24(2):26-36. doi: 10.1016/j.jbmt.2020.01.008. Epub 2020 Feb 6.
Motl RW, Bollaert RE, Sandroff BM Validation of the Godin Leisure-Time Exercise Questionnaire classification coding system using accelerometry in multiple sclerosis. Rehabil Psychol. 2018 Feb;63(1):77-82. doi: 10.1037/rep0000162. Epub 2017 Jul 31.
Oliver GD, Washington JK, Barfield JW, Gascon SS, Gilmer G Quantitative Analysis of Proximal and Distal Kinetic Chain Musculature During Dynamic Exercises. J Strength Cond Res. 2018 Jun;32(6):1545-1553. doi: 10.1519/JSC.0000000000002036.
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Sanchez-Lastra MA, Martinez-Aldao D, Molina AJ, Ayan C Pilates for people with multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord. 2019 Feb;28:199-212. doi: 10.1016/j.msard.2019.01.006. Epub 2019 Jan 3. Erratum In: Mult Scler Relat Disord. 2019 Jul;32:139-140.
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Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
