Chung F, Yang Y, Liao P Predictive performance of the STOP-Bang score for identifying obstructive sleep apnea in obese patients. Obes Surg. 2013 Dec;23(12):2050-7. doi: 10.1007/s11695-013-1006-z.
Dominguez JE, Krystal AD, Habib AS Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management. Anesth Analg. 2018 Nov;127(5):1167-1177. doi: 10.1213/ANE.0000000000003335. Review.
Dominguez JE, Street L, Louis J Management of Obstructive Sleep Apnea in Pregnancy. Obstet Gynecol Clin North Am. 2018 Jun;45(2):233-247. doi: 10.1016/j.ogc.2018.01.001. Review.
Johansson S, Sandström A, Cnattingius S Maternal overweight and obesity increase the risk of fetal acidosis during labor. J Perinatol. 2018 Sep;38(9):1144-1150. doi: 10.1038/s41372-018-0144-5. Epub 2018 Jun 19.
Kelly MC, Fitzpatrick KT, Hill DA Respiratory effects of spinal anaesthesia for caesarean section. Anaesthesia. 1996 Dec;51(12):1120-2.
MacIntyre NR Physiologic Effects of Noninvasive Ventilation. Respir Care. 2019 Jun;64(6):617-628. doi: 10.4187/respcare.06635. Review.
Pearson F, Batterham AM, Cope S The STOP-Bang Questionnaire as a Screening Tool for Obstructive Sleep Apnea in Pregnancy. J Clin Sleep Med. 2019 May 15;15(5):705-710. doi: 10.5664/jcsm.7754.
Polin CM, Hale B, Mauritz AA, Habib AS, Jones CA, Strouch ZY, Dominguez JE Anesthetic management of super-morbidly obese parturients for cesarean delivery with a double neuraxial catheter technique: a case series. Int J Obstet Anesth. 2015 Aug;24(3):276-80. doi: 10.1016/j.ijoa.2015.04.001. Epub 2015 Apr 8.
Simon VB, Fong A, Nageotte MP Supplemental Oxygen Study: A Randomized Controlled Study on the Effect of Maternal Oxygen Supplementation during Planned Cesarean Delivery on Umbilical Cord Gases. Am J Perinatol. 2018 Jan;35(1):84-89. doi: 10.1055/s-0037-1606184. Epub 2017 Aug 24.
Vricella LK, Louis JM, Mercer BM, Bolden N Impact of morbid obesity on epidural anesthesia complications in labor. Am J Obstet Gynecol. 2011 Oct;205(4):370.e1-6. doi: 10.1016/j.ajog.2011.06.085. Epub 2011 Jun 29.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
