Farsi N, Alamoudi N, Balto K, Al Mushayt A Clinical assessment of mineral trioxide aggregate (MTA) as direct pulp capping in young permanent teeth. J Clin Pediatr Dent. 2006 Winter;31(2):72-6.
Gruythuysen RJ, van Strijp AJ, Wu MK Long-term survival of indirect pulp treatment performed in primary and permanent teeth with clinically diagnosed deep carious lesions. J Endod. 2010 Sep;36(9):1490-3. doi: 10.1016/j.joen.2010.06.006. Erratum in: J Endod. 2010 Dec;36(12):2015. Gruythuysen, René [corrected to Gruythuysen, René J M]; van Strijp, Guus [corrected to van Strijp, A J P].
Mejàre I, Cvek M Partial pulpotomy in young permanent teeth with deep carious lesions. Endod Dent Traumatol. 1993 Dec;9(6):238-42.
Nosrat A, Seifi A, Asgary S Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial. Int J Paediatr Dent. 2013 Jan;23(1):56-63. doi: 10.1111/j.1365-263X.2012.01224.x. Epub 2012 Feb 6.
Orstavik D, Kerekes K, Eriksen HM The periapical index: a scoring system for radiographic assessment of apical periodontitis. Endod Dent Traumatol. 1986 Feb;2(1):20-34.
Rajasekharan S, Martens LC, Cauwels RG, Verbeeck RM Biodentine™ material characteristics and clinical applications: a review of the literature. Eur Arch Paediatr Dent. 2014 Jun;15(3):147-58. doi: 10.1007/s40368-014-0114-3. Epub 2014 Mar 11. Review.
Rodd HD, Boissonade FM, Day PF Pulpal status of hypomineralized permanent molars. Pediatr Dent. 2007 Nov-Dec;29(6):514-20.
Seow WK Developmental defects of enamel and dentine: challenges for basic science research and clinical management. Aust Dent J. 2014 Jun;59 Suppl 1:143-54. doi: 10.1111/adj.12104. Epub 2013 Oct 27. Review.
Taha NA, Ahmad MB, Ghanim A Assessment of Mineral Trioxide Aggregate pulpotomy in mature permanent teeth with carious exposures. Int Endod J. 2017 Feb;50(2):117-125. doi: 10.1111/iej.12605. Epub 2016 Jan 30.
Ward J Vital pulp therapy in cariously exposed permanent teeth and its limitations. Aust Endod J. 2002 Apr;28(1):29-37. Review.
William V, Messer LB, Burrow MF Molar incisor hypomineralization: review and recommendations for clinical management. Pediatr Dent. 2006 May-Jun;28(3):224-32. Review.
Witherspoon DE Vital pulp therapy with new materials: new directions and treatment perspectives--permanent teeth. J Endod. 2008 Jul;34(7 Suppl):S25-8. doi: 10.1016/j.joen.2008.02.030. Review.
Outcome of Vital Pulp Therapy in Carious Teeth With Hypomineralization Defects: a Clinical Study
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
