Druss BG, Rosenheck RA Use of practitioner-based complementary therapies by persons reporting mental conditions in the United States. Arch Gen Psychiatry. 2000 Jul;57(7):708-14.
Eisenberg D, Golberstein E, Gollust SE Help-seeking and access to mental health care in a university student population. Med Care. 2007 Jul;45(7):594-601.
Hansen AH, Kristoffersen AE The use of CAM providers and psychiatric outpatient services in people with anxiety/depression: a cross-sectional survey. BMC Complement Altern Med. 2016 Nov 11;16(1):461.
Joyce J, Herbison GP Reiki for depression and anxiety. Cochrane Database Syst Rev. 2015 Apr 3;(4):CD006833. doi: 10.1002/14651858.CD006833.pub2. Review.
Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005 Jun;62(6):593-602. Erratum in: Arch Gen Psychiatry. 2005 Jul;62(7):768. Merikangas, Kathleen R [added].
Kristoffersen AE, Stub T, Knudsen-Baas O, Udal AH, Musial F Self-Reported Effects of Energy Healing: A Prospective Observational Study With Pre-Post Design. Explore (NY). 2019 Mar - Apr;15(2):115-125. doi: 10.1016/j.explore.2018.06.009. Epub 2018 Aug 22.
Montgomery SA, Asberg M A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979 Apr;134:382-9.
Paterson C, Britten N In pursuit of patient-centred outcomes: a qualitative evaluation of the 'Measure Yourself Medical Outcome Profile'. J Health Serv Res Policy. 2000 Jan;5(1):27-36.
Richeson NE, Spross JA, Lutz K, Peng C Effects of Reiki on anxiety, depression, pain, and physiological factors in community-dwelling older adults. Res Gerontol Nurs. 2010 Jul;3(3):187-99. doi: 10.3928/19404921-20100601-01. Epub 2010 Jun 30.
Shore AG Long-term effects of energetic healing on symptoms of psychological depression and self-perceived stress. Altern Ther Health Med. 2004 May-Jun;10(3):42-8. Erratum in: Altern Ther Health Med. 2004 Jul-Aug;10(4):14.
Spinks J, Hollingsworth B Policy implications of complementary and alternative medicine use in Australia: data from the National Health Survey. J Altern Complement Med. 2012 Apr;18(4):371-8. doi: 10.1089/acm.2010.0817.
Steer RA, Cavalieri TA, Leonard DM, Beck AT Use of the Beck Depression Inventory for Primary Care to screen for major depression disorders. Gen Hosp Psychiatry. 1999 Mar-Apr;21(2):106-11.
Thompson TD, Weiss M Homeopathy--what are the active ingredients? An exploratory study using the UK Medical Research Council's framework for the evaluation of complex interventions. BMC Complement Altern Med. 2006 Nov 13;6:37.
Van Aken R, Taylor B Emerging from depression: the experiential process of Healing Touch explored through grounded theory and case study. Complement Ther Clin Pract. 2010 Aug;16(3):132-137. doi: 10.1016/j.ctcp.2009.11.001. Epub 2009 Dec 5.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
