Akaike H A new look at the statistical model identification. IEEE Trans Automat Contr 1974; 19: 716-23.
Andersson JLR, Sotiropoulos SN An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage. 2016 Jan 15;125:1063-1078. doi: 10.1016/j.neuroimage.2015.10.019. Epub 2015 Oct 20.
Aoki KR Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A. Neurotoxicology. 2005 Oct;26(5):785-93. doi: 10.1016/j.neuro.2005.01.017. Epub 2005 Jul 5.
Beissner F, Meissner K, Bar KJ, Napadow V The autonomic brain: an activation likelihood estimation meta-analysis for central processing of autonomic function. J Neurosci. 2013 Jun 19;33(25):10503-11. doi: 10.1523/JNEUROSCI.1103-13.2013.
Bigal ME, Serrano D, Buse D, Scher A, Stewart WF, Lipton RB Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. Headache. 2008 Sep;48(8):1157-68. doi: 10.1111/j.1526-4610.2008.01217.x.
Burstein R, Jakubowski M Unitary hypothesis for multiple triggers of the pain and strain of migraine. J Comp Neurol. 2005 Dec 5;493(1):9-14. doi: 10.1002/cne.20688.
Castillo J, Munoz P, Guitera V, Pascual J Kaplan Award 1998. Epidemiology of chronic daily headache in the general population. Headache. 1999 Mar;39(3):190-6. doi: 10.1046/j.1526-4610.1999.3903190.x.
Dale AM, Fischl B, Sereno MI Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage. 1999 Feb;9(2):179-94. doi: 10.1006/nimg.1998.0395.
Dhollander T, Raffelt D, Connelly A Unsupervised 3-tissue response function estimation from single-shell or multi-shell diffusion MR data without a co-registered T1 image. ISMRM Work Break Barriers Diffus MRI 2016; 5.
Dodick D, Silberstein S Central sensitization theory of migraine: clinical implications. Headache. 2006 Nov;46 Suppl 4:S182-91. doi: 10.1111/j.1526-4610.2006.00602.x.
Fischl B, Liu A, Dale AM Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging. 2001 Jan;20(1):70-80. doi: 10.1109/42.906426.
Fornito A, Bullmore ET Connectomics: a new paradigm for understanding brain disease. Eur Neuropsychopharmacol. 2015 May;25(5):733-48. doi: 10.1016/j.euroneuro.2014.02.011. Epub 2014 Mar 5.
Fusar-Poli P, Smieskova R, Kempton MJ, Ho BC, Andreasen NC, Borgwardt S Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neurosci Biobehav Rev. 2013 Sep;37(8):1680-91. doi: 10.1016/j.neubiorev.2013.06.001. Epub 2013 Jun 14.
Guo S, Vollesen ALH, Olesen J, Ashina M Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine. Pain. 2016 Dec;157(12):2773-2781. doi: 10.1097/j.pain.0000000000000702.
Hagmann P, Jonasson L, Maeder P, Thiran JP, Wedeen VJ, Meuli R Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics. 2006 Oct;26 Suppl 1:S205-23. doi: 10.1148/rg.26si065510.
Jenkinson M, Bannister P, Brady M, Smith S Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002 Oct;17(2):825-41. doi: 10.1016/s1053-8119(02)91132-8.
Jensen K, Tuxen C, Olesen J Pericranial muscle tenderness and pressure-pain threshold in the temporal region during common migraine. Pain. 1988 Oct;35(1):65-70. doi: 10.1016/0304-3959(88)90277-1.
Karsan N, Bose P, Goadsby PJ The Migraine Premonitory Phase. Continuum (Minneap Minn). 2018 Aug;24(4, Headache):996-1008. doi: 10.1212/CON.0000000000000624.
Krebs K, Rorden C, Androulakis XM Resting State Functional Connectivity After Sphenopalatine Ganglion Blocks in Chronic Migraine With Medication Overuse Headache: A Pilot Longitudinal fMRI Study. Headache. 2018 May;58(5):732-743. doi: 10.1111/head.13318.
Noseda R, Kainz V, Borsook D, Burstein R Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One. 2014 Aug 4;9(8):e103929. doi: 10.1371/journal.pone.0103929. eCollection 2014.
Quintela E, Castillo J, Munoz P, Pascual J Premonitory and resolution symptoms in migraine: a prospective study in 100 unselected patients. Cephalalgia. 2006 Sep;26(9):1051-60. doi: 10.1111/j.1468-2982.2006.01157.x.
Reuter M, Schmansky NJ, Rosas HD, Fischl B Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage. 2012 Jul 16;61(4):1402-18. doi: 10.1016/j.neuroimage.2012.02.084. Epub 2012 Mar 10.
Schulte LH, May A The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain. 2016 Jul;139(Pt 7):1987-93. doi: 10.1093/brain/aww097. Epub 2016 May 5.
Smith RE, Tournier JD, Calamante F, Connelly A Anatomically-constrained tractography: improved diffusion MRI streamlines tractography through effective use of anatomical information. Neuroimage. 2012 Sep;62(3):1924-38. doi: 10.1016/j.neuroimage.2012.06.005. Epub 2012 Jun 13.
Smith RE, Tournier JD, Calamante F, Connelly A SIFT2: Enabling dense quantitative assessment of brain white matter connectivity using streamlines tractography. Neuroimage. 2015 Oct 1;119:338-51. doi: 10.1016/j.neuroimage.2015.06.092. Epub 2015 Jul 8.
Smith SM Fast robust automated brain extraction. Hum Brain Mapp. 2002 Nov;17(3):143-55. doi: 10.1002/hbm.10062.
Stankewitz A, Aderjan D, Eippert F, May A Trigeminal nociceptive transmission in migraineurs predicts migraine attacks. J Neurosci. 2011 Feb 9;31(6):1937-43. doi: 10.1523/JNEUROSCI.4496-10.2011.
Tournier J-D, Calamante F, Connelly A Improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions. Proc Int Soc Magn Reson Med. 2010; 1670.
Tournier JD, Calamante F, Connelly A Determination of the appropriate b value and number of gradient directions for high-angular-resolution diffusion-weighted imaging. NMR Biomed. 2013 Dec;26(12):1775-86. doi: 10.1002/nbm.3017. Epub 2013 Aug 29.
Tournier JD, Calamante F, Connelly A Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. Neuroimage. 2007 May 1;35(4):1459-72. doi: 10.1016/j.neuroimage.2007.02.016. Epub 2007 Feb 21.
Tournier JD, Calamante F, Gadian DG, Connelly A Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution. Neuroimage. 2004 Nov;23(3):1176-85. doi: 10.1016/j.neuroimage.2004.07.037.
Whitfield-Gabrieli S, Nieto-Castanon A Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect. 2012;2(3):125-41. doi: 10.1089/brain.2012.0073. Epub 2012 Jul 19.
Yrondi A, Peran P, Sauvaget A, Schmitt L, Arbus C Structural-functional brain changes in depressed patients during and after electroconvulsive therapy. Acta Neuropsychiatr. 2018 Feb;30(1):17-28. doi: 10.1017/neu.2016.62. Epub 2016 Nov 23.
Zhang Y, Brady M, Smith S Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging. 2001 Jan;20(1):45-57. doi: 10.1109/42.906424.
A Prospective Structural, Diffusion and Connectomics MRI Study on Migraine Patients Treated With Fremanezumab: The FreMRI Study
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.