NCT05516251 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Ordás CM, Cuadrado ML, Pareja JA, de-Las-Casas-Cámara G, Gómez-Vicente L, Torres-Gaona G, Venegas-Pérez B, Álvarez-Mariño B, Diez Barrio A, Pardo-Moreno J
Transcutaneous Supraorbital Stimulation as a Preventive Treatment for Chronic Migraine: A Prospecti
Riederer F, Penning S, Schoenen J
Transcutaneous Supraorbital Nerve Stimulation (t-SNS) with the Cefaly(®) Device for Migraine Prevention: A Review of the Available Data. Pain Ther. 2015 Oct 14. [Epub ahead of print]
Vikelis M, Dermitzakis EV, Spingos KC, Vasiliadis GG, Vlachos GS, Kararizou E
Clinical experience with transcutaneous supraorbital nerve stimulation in patients with refractory migraine or with migraine and intolerance to topiramate: a prospective explor

Transcutaneous Supraorbital Nerve Stimulator Versus Topiramate in Prevention of Recurrent Migraine: A Prospective, Randomized Comparative Study.

Clinical trial NCT05516251 - References