Micrognathia — Functional Modeling of the Pediatric Airway
Citation(s)
Calloway, E H., Kimbell, J.S., Davis, S.D., Retsch-Bogart, G.Z., Pitkin, E.A., Abode, K., Superfine, R.,and Zdanski, C.J. (2012). Comparison of Endoscopic versus 3D CT Derived Airway Measurements. Podium presentation, The Triological, Society Combined Otolaryngological Spring Meetings, San Diego, CA, USA, April 18-22, 2012, Submitted to The Laryngoscope, 3/26/2012.
Mitran S Continuum-kinetic-microscopic model of lung clearance due to core-annular fluid entrainment. J Comput Phys. 2013 Jul 1;244:193-211.
Mitran, S (2012b), "Lattice Fokker-Planck Method Based on Wasserstein Gradient Flows", Phys. Rev.E., (under review).
Oluwafemi S Alabi, Xunlei Wu, Steffen Bass, Scott Pratt, Sharon Zhong, Chris Healey, Russell M.Taylor II, "Exploring Ensemble Data Sets Through Ensemble Surface Slicing," Proceedings of SPIEVisualization and Data Analysis 2012. Proceedings of the SPIE, Volume 8294, pp. U1-U12.
Zdanski, C , Kimbell, J.S., Superfine, R.S., and Davis, S. (2012). Computational Fluid Dynamics Modeling of the Pediatric Airway Utilizing Computed Tomography in Children with Pierre Robin Sequence. Poster presentation, European Society of Pediatric Otolaryngology, Amsterdam, The Netherlands, May 20-23, 2012.
Predictive Modeling for Treatment of Upper Airway Obstruction in Young Children
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
