Axelsson B, Christensen SB Evaluation of a hospital-based palliative support service with particular regard to financial outcome measures. Palliat Med. 1998 Jan;12(1):41-9.
Bass DM, Bowman K, Noelker LS The influence of caregiving and bereavement support on adjusting to an older relative's death. Gerontologist. 1991 Feb;31(1):32-42.
Bass DM, Noelker LS, Rechlin LR The moderating influence of service use on negative caregiving consequences. J Gerontol B Psychol Sci Soc Sci. 1996 May;51(3):S121-31.
Billings JA, Pantilat S Survey of palliative care programs in United States teaching hospitals. J Palliat Med. 2001 Fall;4(3):309-14.
Billings JA What is palliative care? J Palliat Med. 1998 Spring;1(1):73-81.
Block SD Perspectives on care at the close of life. Psychological considerations, growth, and transcendence at the end of life: the art of the possible. JAMA. 2001 Jun 13;285(22):2898-905.
Bruera E ABC of palliative care. Anorexia, cachexia, and nutrition. BMJ. 1997 Nov 8;315(7117):1219-22. Review.
Burge F, Lawson B, Johnston G Family physician continuity of care and emergency department use in end-of-life cancer care. Med Care. 2003 Aug;41(8):992-1001.
Byock I Completing the continuum of cancer care: integrating life-prolongation and palliation. CA Cancer J Clin. 2000 Mar-Apr;50(2):123-32. Review.
Center to Advance Palliative Care A Guide to Developing a Hospital-Based Palliative Care Program. New York: Center to Advance Palliative Care; 2004.
Chan GK End-of-life models and emergency department care. Acad Emerg Med. 2004 Jan;11(1):79-86. Review.
Ciemins EL, Blum L, Nunley M, Lasher A, Newman JM The economic and clinical impact of an inpatient palliative care consultation service: a multifaceted approach. J Palliat Med. 2007 Dec;10(6):1347-55.
Cowan JD Hospital charges for a community inpatient palliative care program. Am J Hosp Palliat Care. 2004 May-Jun;21(3):177-90.
DeFrances CJ, Hall MJ 2002 National Hospital Discharge Survey. Adv Data. 2004 May 21;(342):1-29.
Donnelly S, Walsh D The symptoms of advanced cancer. Semin Oncol. 1995 Apr;22(2 Suppl 3):67-72.
Emanuel EJ, Fairclough DL, Slutsman J, Emanuel LL Understanding economic and other burdens of terminal illness: the experience of patients and their caregivers. Ann Intern Med. 2000 Mar 21;132(6):451-9.
Eng C, Pedulla J, Eleazer GP, McCann R, Fox N Program of All-inclusive Care for the Elderly (PACE): an innovative model of integrated geriatric care and financing. J Am Geriatr Soc. 1997 Feb;45(2):223-32.
Goldsmith B, Dietrich J, Du Q, Morrison RS Variability in access to hospital palliative care in the United States. J Palliat Med. 2008 Oct;11(8):1094-102. doi: 10.1089/jpm.2008.0053.
Hanson LC, Usher B, Spragens L, Bernard S Clinical and economic impact of palliative care consultation. J Pain Symptom Manage. 2008 Apr;35(4):340-6. doi: 10.1016/j.jpainsymman.2007.06.008. Epub 2008 Feb 8.
Institute of Medicine (U S.). Committee on Palliative and End-of-Life Care for Children and Their Families. Ethical and legal issues. Washington, D.C.: Institute of Medicine, National Academies Press; 2003.
Levine C The loneliness of the long-term care giver. N Engl J Med. 1999 May 20;340(20):1587-90.
Lo B, Quill T, Tulsky J Discussing palliative care with patients. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. Ann Intern Med. 1999 May 4;130(9):744-9. Review.
Lubitz JD, Riley GF Trends in Medicare payments in the last year of life. N Engl J Med. 1993 Apr 15;328(15):1092-6.
Lynn J, Wilkinson AM Quality end of life care: the case for a MediCaring demonstration. Hosp J. 1998;13(1-2):151-63. Review.
Lynn J Learning to care for people with chronic illness facing the end of life. JAMA. 2000 Nov 15;284(19):2508-11.
Lynn J Perspectives on care at the close of life. Serving patients who may die soon and their families: the role of hospice and other services. JAMA. 2001 Feb 21;285(7):925-32.
McClain CS, Rosenfeld B, Breitbart W Effect of spiritual well-being on end-of-life despair in terminally-ill cancer patients. Lancet. 2003 May 10;361(9369):1603-7.
McKinley ED, Garrett JM, Evans AT, Danis M Differences in end-of-life decision making among black and white ambulatory cancer patients. J Gen Intern Med. 1996 Nov;11(11):651-6.
McMillan SC, Small BJ Using the COPE intervention for family caregivers to improve symptoms of hospice homecare patients: a clinical trial. Oncol Nurs Forum. 2007 Mar;34(2):313-21.
National Quality Forum A national framework and preferred practices for palliative and hospice care quality : a consensus report. Washington, DC: National Quality Forum; 2006.
Portenoy RK, Frager G Pain management: pharmacological approaches. Cancer Treat Res. 1999;100:1-29. Review.
Quill TE, Arnold RM, Platt F "I wish things were different": expressing wishes in response to loss, futility, and unrealistic hopes. Ann Intern Med. 2001 Oct 2;135(7):551-5.
Quill TE Perspectives on care at the close of life. Initiating end-of-life discussions with seriously ill patients: addressing the "elephant in the room". JAMA. 2000 Nov 15;284(19):2502-7.
Rabow MW, Dibble SL, Pantilat SZ, McPhee SJ The comprehensive care team: a controlled trial of outpatient palliative medicine consultation. Arch Intern Med. 2004 Jan 12;164(1):83-91.
von Gunten CF, Ferris FD, Emanuel LL The patient-physician relationship. Ensuring competency in end-of-life care: communication and relational skills. JAMA. 2000 Dec 20;284(23):3051-7.
von Gunten CF Secondary and tertiary palliative care in US hospitals. JAMA. 2002 Feb 20;287(7):875-81.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.