Bachmann S Epidemiology of Suicide and the Psychiatric Perspective. Int J Environ Res Public Health. 2018 Jul 6;15(7). pii: E1425. doi: 10.3390/ijerph15071425. Review.
Breton JJ, Tousignant M, Bergeron L, Berthiaume C Informant-specific correlates of suicidal behavior in a community survey of 12- to 14-year-olds. J Am Acad Child Adolesc Psychiatry. 2002 Jun;41(6):723-30.
McLoughlin AB, Gould MS, Malone KM Global trends in teenage suicide: 2003-2014. QJM. 2015 Oct;108(10):765-80. doi: 10.1093/qjmed/hcv026. Epub 2015 Jan 31. Review.
Miranda R, De Jaegere E, Restifo K, Shaffer D Longitudinal follow-up study of adolescents who report a suicide attempt: aspects of suicidal behavior that increase risk of a future attempt. Depress Anxiety. 2014 Jan;31(1):19-26. doi: 10.1002/da.22194. Epu
Miranda R, Shaffer D Understanding the suicidal moment in adolescence. Ann N Y Acad Sci. 2013 Nov;1304:14-21. doi: 10.1111/nyas.12291. Epub 2013 Oct 18.
Roh BR, Jung EH, Hong HJ A Comparative Study of Suicide Rates among 10-19-Year-Olds in 29 OECD Countries. Psychiatry Investig. 2018 Apr;15(4):376-383. doi: 10.30773/pi.2017.08.02. Epub 2018 Feb 28.
Schrijvers DL, Bollen J, Sabbe BG The gender paradox in suicidal behavior and its impact on the suicidal process. J Affect Disord. 2012 Apr;138(1-2):19-26. doi: 10.1016/j.jad.2011.03.050. Epub 2011 May 6. Review.
Shain B; COMMITTEE ON ADOLESCENCE Suicide and Suicide Attempts in Adolescents. Pediatrics. 2016 Jul;138(1). pii: e20161420. doi: 10.1542/peds.2016-1420.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
