Medication Non-adherence — Improving Adherence and Outcomes by Artificial Intelligence-Adapted Text Messages
Citation(s)
Coleman MT, Newton KS Supporting self-management in patients with chronic illness. Am Fam Physician. 2005 Oct 15;72(8):1503-10. Review.
Elliott RA, Shinogle JA, Peele P, Bhosle M, Hughes DA Understanding medication compliance and persistence from an economics perspective. Value Health. 2008 Jul-Aug;11(4):600-10. doi: 10.1111/j.1524-4733.2007.00304.x. Epub 2008 Jan 8.
Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD000011. doi: 10.1002/14651858.CD000011.pub3. Review. Update in: Cochrane Database Syst Rev. 2014;11:CD000011.
Lawn S, Schoo A Supporting self-management of chronic health conditions: common approaches. Patient Educ Couns. 2010 Aug;80(2):205-11. doi: 10.1016/j.pec.2009.10.006. Review.
Marx G, Witte N, Himmel W, Kühnel S, Simmenroth-Nayda A, Koschack J Accepting the unacceptable: medication adherence and different types of action patterns among patients with high blood pressure. Patient Educ Couns. 2011 Dec;85(3):468-74. doi: 10.1016/j.pec.2011.04.011. Epub 2011 May 19.
Munger MA, Van Tassell BW, LaFleur J Medication nonadherence: an unrecognized cardiovascular risk factor. MedGenMed. 2007 Sep 19;9(3):58. Review.
NEHI Thinking outside the pillbox: a system-wide approach to improving patient medication adherence for chronic disease. http://www.nehi.net/publications/44/thinking_outside_the_pillbox_a_systemwide_approach_to_improving_patient_medication_adherence_for_chronic_disease, Accessed 09 12 12
Osterberg L, Blaschke T Adherence to medication. N Engl J Med. 2005 Aug 4;353(5):487-97. Review.
Sabate E - World Health Organization Adherence to long-term therapies: evidence for action. 2003. http://apps.who.int/medicinedocs/en/d/Js4883e/, Accessed 09 12 12
Vervloet M, Linn AJ, van Weert JC, de Bakker DH, Bouvy ML, van Dijk L The effectiveness of interventions using electronic reminders to improve adherence to chronic medication: a systematic review of the literature. J Am Med Inform Assoc. 2012 Sep-Oct;19(5):696-704. doi: 10.1136/amiajnl-2011-000748. Epub 2012 Apr 25. Review.
Vrijens B, Vincze G, Kristanto P, Urquhart J, Burnier M Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ. 2008 May 17;336(7653):1114-7. doi: 10.1136/bmj.39553.670231.25. Epub 2008 May 14.
Improving Adherence and Outcomes by Artificial Intelligence-Adapted Text Messages
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.