Malaria Anaemia — Chloroquine and Post Malaria Anaemia Study
Citation(s)
1 Weatherall DJ, et al. Br Med Bull 1982;38(2):147-51. 2. Schwartz RS, et al.Blood 1987;69(2):401-7. 4. Looareesuwan S, et al. Acta Trop 1991;48(4):263-70. 5. Abdalla SH, et al. Clin Lab Haematol 1988;10(1):33-40. 6. Jootar S, et al. Clin Lab Haematol 1993;15(2):87-92. 7. Jason J, et al. Clin Immunol 2001;100(2):208-18. 8. Clark IA, et al. Br J Haematol 1988;70(1):99-103. 9. Biemba G, et al. Trop Med Int Health 2000;5(4):256-62. 10. Othoro C, et al, J Infect Dis 1999;179(1):279-82. 11. Luty AJ, et al. Infect Immun 2000;68(7):3909-15. 12. Camacho LH, et al. Ann Trop Med Parasitol 1998;92(5):525-37. 13. Kwiatkowski D, et al. Clin Exp Immunol 1989;77(3):361-6. 15. Wenisch C, et al. Clin Immunol Immunopathol 1995;74(1):115-7. 17. Helleberg M, et al. Malar J 2005;4(1):56. 18. Knutson M, et al, Crit Rev Biochem Mol Biol 2003;38(1):61-88. 23. Abdalla S, et al. Br J Haematol 1980;46(2):171-83. 24. Bojang KA, et al. Trans R Soc Trop Med Hyg 1997;91(5):557-61. 30. Moore HP, et al. Nature 1983;302(5907):434-6. 31. Agarwal SL, et al, Arch Int Pharmacodyn Ther 1963;143:401-7. 32. Ayitey-Smith E, et al. J Pharm Pharmacol 1974;26(3):208-9. 33. Moss RB. Chest 1995;107(3):817-25. 34. Lancz GJ, et al. Proc Soc Exp Biol Med 1971;136(4):1289-93. 35. Tsai WP, et al. AIDS Res Hum Retroviruses 1990;6(4):481-9. 36. Boelaert JR, et al. J Acquir Immune Defic Syndr 2001;26(3):300-1. 37. Neale ML, et al.Immunology 1988;64(1):81-5. 39. Cash JM, et al. N Engl J Med 1994;330(19):1368-75. 40. Legssyer R, et al. Biochem Pharmacol 1999;57(8):907-11. 41. Salihu HM, et al. Trop Med Int Health 2002;7(1):29-34. 42. Cot M, le Hesran JY, et al. Ann Trop Med Parasitol 1998;92(1):37-43.
Chloroquine as a Therapeutic Option for Mild Post Malaria Anaemia
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
