Clinical trial NCT01236586 - References

Lymphoma — RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia

Citation(s)

•   Artavanis-Tsakonas S, Rand MD, Lake RJ
  Notch signaling: cell fate control and signal integration in development. Science. 1999 Apr 30;284(5415):770-6. Review.
•   Bray SJ
  Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006 Sep;7(9):678-89. Review.
•   Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE
  Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene. 2005 Sep 22;24(42):6333-44.

A Phase 1/2 Study of RO4929097, An Oral Small Molecule Inhibitor of Gamma-Secretase, in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia

Details for clinical trial NCT01236586