Biasi L, Ali T, Ratnam LA, Morgan R, Loftus I, Thompson M Intra-operative DynaCT improves technical success of endovascular repair of abdominal aortic aneurysms. J Vasc Surg. 2009 Feb;49(2):288-95. doi: 10.1016/j.jvs.2008.09.013. Epub 2008 Nov 28.
Chao YK, Pan KT, Wen CT, Fang HY, Hsieh MJ A comparison of efficacy and safety of preoperative versus intraoperative computed tomography-guided thoracoscopic lung resection. J Thorac Cardiovasc Surg. 2018 Nov;156(5):1974-1983.e1. doi: 10.1016/j.jtcvs.2018.06.088. Epub 2018 Jul 20.
Chao YK, Wen CT, Fang HY, Hsieh MJ A single-center experience of 100 image-guided video-assisted thoracoscopic surgery procedures. J Thorac Dis. 2018 Jun;10(Suppl 14):S1624-S1630. doi: 10.21037/jtd.2018.04.44.
Cheng C, Fang HY, Wen CT, Chao YK Real-time image-guided electromagnetic navigation bronchoscopy dual-marker technique to localize deep pulmonary nodules in a hybrid operating room. Eur J Cardiothorac Surg. 2020 Aug 1;58(Suppl_1):i103-i105. doi: 10.1093/ejcts/ezz360.
Fang HY, Chang KW, Chao YK Hybrid operating room for the intraoperative CT-guided localization of pulmonary nodules. Ann Transl Med. 2019 Jan;7(2):34. doi: 10.21037/atm.2018.12.48. Review.
Fang HY, Chao YK, Hsieh MJ, Wen CT, Ho PH, Tang WJ, Liu YH Image-guided video-assisted thoracoscopic surgery for small ground glass opacities: a case series. J Vis Surg. 2017 Oct 18;3:142. doi: 10.21037/jovs.2017.09.08. eCollection 2017.
Finley RJ, Mayo JR, Grant K, Clifton JC, English J, Leo J, Lam S Preoperative computed tomography-guided microcoil localization of small peripheral pulmonary nodules: a prospective randomized controlled trial. J Thorac Cardiovasc Surg. 2015 Jan;149(1):26-31. doi: 10.1016/j.jtcvs.2014.08.055. Epub 2014 Sep 16.
Hsieh MJ, Wen CT, Fang HY, Wen YW, Lin CC, Chao YK Learning curve of image-guided video-assisted thoracoscopic surgery for small pulmonary nodules: A prospective analysis of 30 initial patients. J Thorac Cardiovasc Surg. 2018 Apr;155(4):1825-1832.e1. doi: 10.1016/j.jtcvs.2017.11.079. Epub 2017 Dec 13.
Huang HL, Kung PT, Chiu CF, Wang YH, Tsai WC Factors associated with lung cancer patients refusing treatment and their survival: a national cohort study under a universal health insurance in Taiwan. PLoS One. 2014 Jul 7;9(7):e101731. doi: 10.1371/journal.pone.0101731. eCollection 2014.
Kpodonu J, Raney A The cardiovascular hybrid room a key component for hybrid interventions and image guided surgery in the emerging specialty of cardiovascular hybrid surgery. Interact Cardiovasc Thorac Surg. 2009 Oct;9(4):688-92. doi: 10.1510/icvts.2009.209429. Epub 2009 Jul 21. Review.
Sadoughi A, Virdi S Mobile 3D Intraprocedural Fluoroscopy in Combination With Ultrathin Bronchoscopy for Biopsy of Peripheral Lung Nodules. J Bronchology Interv Pulmonol. 2021 Jan 1;28(1):76-80. doi: 10.1097/LBR.0000000000000711.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.