Lung Transplant Failure — Respiratory Physiotherapy as a Tool to Increase the Number of Solid Organ Donors
Citation(s)
Bach JR, Saporito LR, Shah HR, Sinquee D Decanulation of patients with severe respiratory muscle insufficiency: efficacy of mechanical insufflation-exsufflation. J Rehabil Med. 2014 Nov;46(10):1037-41. doi: 10.2340/16501977-1874.
Bach JR Noninvasive Respiratory Management of Patients With Neuromuscular Disease. Ann Rehabil Med. 2017 Aug;41(4):519-538. doi: 10.5535/arm.2017.41.4.519. Epub 2017 Aug 31.
Goncalves MR, Honrado T, Winck JC, Paiva JA Effects of mechanical insufflation-exsufflation in preventing respiratory failure after extubation: a randomized controlled trial. Crit Care. 2012 Dec 12;16(2):R48. doi: 10.1186/cc11249.
Lachal R, Louis B, Subtil F, Guerin C Bench Assessment of the Effect of a Collapsible Tube on the Efficiency of a Mechanical Insufflation-Exsufflation Device. Respir Care. 2019 Jul;64(7):752-759. doi: 10.4187/respcare.06478. Epub 2019 Mar 12.
Morrow B, Zampoli M, van Aswegen H, Argent A Mechanical insufflation-exsufflation for people with neuromuscular disorders. Cochrane Database Syst Rev. 2013 Dec 30;(12):CD010044. doi: 10.1002/14651858.CD010044.pub2.
Rose L Strategies for weaning from mechanical ventilation: a state of the art review. Intensive Crit Care Nurs. 2015 Aug;31(4):189-95. doi: 10.1016/j.iccn.2015.07.003. Epub 2015 Jul 21.
Stiller K Physiotherapy in intensive care: an updated systematic review. Chest. 2013 Sep;144(3):825-847. doi: 10.1378/chest.12-2930.
Terzi N, Prigent H, Lofaso F Mechanical Insufflation-Exsufflation to Improve Secretion Clearance During Invasive Ventilation. Respir Care. 2018 Dec;63(12):1577-1578. doi: 10.4187/respcare.06700. No abstract available.
Toussaint M The use of mechanical insufflation-exsufflation via artificial airways. Respir Care. 2011 Aug;56(8):1217-9. doi: 10.4187/respcare.01448. No abstract available.
Volpe MS, Naves JM, Ribeiro GG, Ruas G, Amato MBP Airway Clearance With an Optimized Mechanical Insufflation-Exsufflation Maneuver. Respir Care. 2018 Oct;63(10):1214-1222. doi: 10.4187/respcare.05965. Epub 2018 Jul 17.
Respiratory Physiotherapy as a Tool to Increase the Number of Solid Organ Donors
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
