Lung Diseases — Epidemiology of Interstitial Lung Disease
Citation(s)
Coultas DB, Hughes MP Accuracy of mortality data for interstitial lung diseases in New Mexico, USA. Thorax. 1996 Jul;51(7):717-20. doi: 10.1136/thx.51.7.717.
Coultas DB, Zumwalt RE, Black WC, Sobonya RE The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med. 1994 Oct;150(4):967-72. doi: 10.1164/ajrccm.150.4.7921471.
Mapel DW, Samet JM, Coultas DB Corticosteroids and the treatment of idiopathic pulmonary fibrosis. Past, present, and future. Chest. 1996 Oct;110(4):1058-67. doi: 10.1378/chest.110.4.1058. No abstract available.
Mulloy KB, Coultas DB, Samet JM Use of chest radiographs in epidemiological investigations of pneumoconioses. Br J Ind Med. 1993 Mar;50(3):273-5. doi: 10.1136/oem.50.3.273.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
