Bevan S Economic impact of musculoskeletal disorders (MSDs) on work in Europe. Best Pract Res Clin Rheumatol. 2015 Jun;29(3):356-73. doi: 10.1016/j.berh.2015.08.002. Epub 2015 Oct 24.
Borghouts JAJ, Koes BW, Bouter LM The clinical course and prognostic factors of non-specific neck pain: a systematic review. Pain. 1998 Jul;77(1):1-13. doi: 10.1016/S0304-3959(98)00058-X.
Delgado Conforme, W A., Abarca López, J. J., Boada Rodríguez, L. E., & Salazar Trujillo, S. E. (2019). Lumbalgia inespecífica. Dolencia más común de lo que se cree. RECIMUNDO, 3(2), 3-25. https://doi.org/10.26820/recimundo/3.(2).abril.2019.3-25
Hjornevik T, Jacobsen LM, Qu H, Bjaalie JG, Gjerstad J, Willoch F Metabolic plasticity in the supraspinal pain modulating circuitry after noxious stimulus-induced spinal cord LTP. Pain. 2008 Dec;140(3):456-464. doi: 10.1016/j.pain.2008.09.029. Epub 2008 Nov 11.
Huang Y, Chen SR, Chen H, Zhou JJ, Jin D, Pan HL Theta-Burst Stimulation of Primary Afferents Drives Long-Term Potentiation in the Spinal Cord and Persistent Pain via alpha2delta-1-Bound NMDA Receptors. J Neurosci. 2022 Jan 19;42(3):513-527. doi: 10.1523/JNEUROSCI.1968-21.2021. Epub 2021 Dec 8.
Johnson MI, Paley CA, Jones G, Mulvey MR, Wittkopf PG Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS study). BMJ Open. 2022 Feb 10;12(2):e051073. doi: 10.1136/bmjopen-2021-051073.
Lall MP, Restrepo E The Biopsychosocial Model of Low Back Pain and Patient-Centered Outcomes Following Lumbar Fusion. Orthop Nurs. 2017 May/Jun;36(3):213-221. doi: 10.1097/NOR.0000000000000350.
Larson J, Munkacsy E Theta-burst LTP. Brain Res. 2015 Sep 24;1621:38-50. doi: 10.1016/j.brainres.2014.10.034. Epub 2014 Oct 27.
Larson J, Wong D, Lynch G Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation. Brain Res. 1986 Mar 19;368(2):347-50. doi: 10.1016/0006-8993(86)90579-2.
Popescu A, Lee H Neck Pain and Lower Back Pain. Med Clin North Am. 2020 Mar;104(2):279-292. doi: 10.1016/j.mcna.2019.11.003. Epub 2019 Dec 20.
Rampazo EP, Martignago CCS, de Noronha M, Liebano RE Transcutaneous electrical stimulation in neck pain: A systematic review and meta-analysis. Eur J Pain. 2022 Jan;26(1):18-42. doi: 10.1002/ejp.1845. Epub 2021 Aug 3.
Ranck JB Jr Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. I. Behavioral correlates and firing repertoires. Exp Neurol. 1973 Nov;41(2):461-531. doi: 10.1016/0014-4886(73)90290-2. No abstract available.
Rudell AP, Fox SE, Ranck JB Jr Hippocampal excitability phase-locked to the theta rhythm in walking rats. Exp Neurol. 1980 Apr;68(1):87-96. doi: 10.1016/0014-4886(80)90068-0. No abstract available.
Svendsen F, Tjolsen A, Hole K LTP of spinal A beta and C-fibre evoked responses after electrical sciatic nerve stimulation. Neuroreport. 1997 Nov 10;8(16):3427-30. doi: 10.1097/00001756-199711100-00002.
Van Breukelen GJ ANCOVA versus change from baseline: more power in randomized studies, more bias in nonrandomized studies [corrected]. J Clin Epidemiol. 2006 Sep;59(9):920-5. doi: 10.1016/j.jclinepi.2006.02.007. Epub 2006 Jun 23. Erratum In: J Clin Epidemiol. 2006 Dec;59(12):1334.
Wall PD, Sweet WH Temporary abolition of pain in man. Science. 1967 Jan 6;155(3758):108-9. doi: 10.1126/science.155.3758.108.
Wu J, Hu Q, Huang D, Chen X, Chen J Effect of electrical stimulation of sciatic nerve on synaptic plasticity of spinal dorsal horn and spinal c-fos expression in neonatal, juvenile and adult rats. Brain Res. 2012 Apr 11;1448:11-9. doi: 10.1016/j.brainres.2012.02.002. Epub 2012 Feb 13.
Yang F, Guo J, Sun WL, Liu FY, Cai J, Xing GG, Wan Y The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats. Neuroscience. 2014 Jun 6;269:59-66. doi: 10.1016/j.neuroscience.2014.03.037. Epub 2014 Mar 26.
Effects of Percutaneous Peripheral Nerve Stimulation on Neck and Low Back Pain: a Quadruple-blinded, Randomized Clinical Trial
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.