Boekhout JM, Volders E, Bolman CAW, de Groot RHM, Lechner L Long-Term Effects on Loneliness of a Computer-Tailored Intervention for Older Adults With Chronic Diseases: A Randomized Controlled Trial. J Aging Health. 2021 Dec;33(10):865-876. doi: 10.1177/08982643211015027. Epub 2021 May 7.
Cacioppo JT, Hawkley LC, Thisted RA Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. Psychol Aging. 2010 Jun;25(2):453-63. doi: 10.1037/a0017216.
Czaja SJ, Boot WR, Charness N, Rogers WA, Sharit J Improving Social Support for Older Adults Through Technology: Findings From the PRISM Randomized Controlled Trial. Gerontologist. 2018 May 8;58(3):467-477. doi: 10.1093/geront/gnw249.
De Jong Gierveld J, Van Tilburg T The De Jong Gierveld short scales for emotional and social loneliness: tested on data from 7 countries in the UN generations and gender surveys. Eur J Ageing. 2010 Jun;7(2):121-130. doi: 10.1007/s10433-010-0144-6. Epub 2010 Apr 9.
Fakoya OA, McCorry NK, Donnelly M Loneliness and social isolation interventions for older adults: a scoping review of reviews. BMC Public Health. 2020 Feb 14;20(1):129. doi: 10.1186/s12889-020-8251-6.
Gardiner C, Geldenhuys G, Gott M Interventions to reduce social isolation and loneliness among older people: an integrative review. Health Soc Care Community. 2018 Mar;26(2):147-157. doi: 10.1111/hsc.12367. Epub 2016 Jul 13.
Hawkley LC, Cacioppo JT Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann Behav Med. 2010 Oct;40(2):218-27. doi: 10.1007/s12160-010-9210-8.
Hawkley LC, Preacher KJ, Cacioppo JT Loneliness impairs daytime functioning but not sleep duration. Health Psychol. 2010 Mar;29(2):124-9. doi: 10.1037/a0018646.
Hughes ME, Waite LJ, Hawkley LC, Cacioppo JT A Short Scale for Measuring Loneliness in Large Surveys: Results From Two Population-Based Studies. Res Aging. 2004;26(6):655-672. doi: 10.1177/0164027504268574.
Knox SS, Uvnas-Moberg K Social isolation and cardiovascular disease: an atherosclerotic pathway? Psychoneuroendocrinology. 1998 Nov;23(8):877-90. doi: 10.1016/s0306-4530(98)00061-4.
Luo Y, Hawkley LC, Waite LJ, Cacioppo JT Loneliness, health, and mortality in old age: a national longitudinal study. Soc Sci Med. 2012 Mar;74(6):907-14. doi: 10.1016/j.socscimed.2011.11.028. Epub 2012 Jan 25.
Masi CM, Chen HY, Hawkley LC, Cacioppo JT A meta-analysis of interventions to reduce loneliness. Pers Soc Psychol Rev. 2011 Aug;15(3):219-66. doi: 10.1177/1088868310377394. Epub 2010 Aug 17.
Perissinotto CM, Stijacic Cenzer I, Covinsky KE Loneliness in older persons: a predictor of functional decline and death. Arch Intern Med. 2012 Jul 23;172(14):1078-83. doi: 10.1001/archinternmed.2012.1993.
Russell DW UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. J Pers Assess. 1996 Feb;66(1):20-40. doi: 10.1207/s15327752jpa6601_2.
Valtorta N, Hanratty B Loneliness, isolation and the health of older adults: do we need a new research agenda? J R Soc Med. 2012 Dec;105(12):518-22. doi: 10.1258/jrsm.2012.120128. No abstract available.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.