Liver Cirrhosis — Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
Citation(s)
Agarwal A, Sharma N, Vij V Point-of-care coagulation monitoring during liver transplantation. Trends in Anaesth and Crit Care. 2013;3:42-48.
Bauters A, Mazoyer E Apport de la thromboe ´lastome ´trie rotative (ROTEM) pour l'exploration de l'he ´mostase: inte ´reˆt en pratique clinique. Revue francophone des laboratoires 2007; 393: 45-50
Davenport R, Khan S Management of major trauma haemorrhage: treatment priorities and controversies. Br J Haematol. 2011 Dec;155(5):537-48. doi: 10.1111/j.1365-2141.2011.08885.x. Epub 2011 Oct 21. Review.
Ganter MT, Hofer CK Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg. 2008 May;106(5):1366-75. doi: 10.1213/ane.0b013e318168b367. Review.
Liu LL, Niemann CU Intraoperative management of liver transplant patients. Transplant Rev (Orlando). 2011 Jul;25(3):124-9. doi: 10.1016/j.trre.2010.10.006. Epub 2011 Apr 21. Review.
Liu S, Fan J, Wang X, Gong Z, Wang S, Huang L, Xing T, Li T, Peng Z, Sun X Intraoperative cryoprecipitate transfusion and its association with the incidence of biliary complications after liver transplantation--a retrospective cohort study. PLoS One. 2013 May 10;8(5):e60727. doi: 10.1371/journal.pone.0060727. Print 2013.
Romero FA, Razonable RR Infections in liver transplant recipients. World J Hepatol. 2011 Apr 27;3(4):83-92. doi: 10.4254/wjh.v3.i4.83.
Saner FH, Gieseler RK, Akiz H, Canbay A, Görlinger K Delicate balance of bleeding and thrombosis in end-stage liver disease and liver transplantation. Digestion. 2013;88(3):135-44. doi: 10.1159/000354400. Epub 2013 Sep 5. Review.
Spahn DR, Casutt M Eliminating blood transfusions: new aspects and perspectives. Anesthesiology. 2000 Jul;93(1):242-55. Review.
Tanaka KA, Bader SO, Görlinger K Novel approaches in management of perioperative coagulopathy. Curr Opin Anaesthesiol. 2014 Feb;27(1):72-80. doi: 10.1097/ACO.0000000000000025. Review.
Tanaka KA, Bolliger D, Vadlamudi R, Nimmo A Rotational thromboelastometry (ROTEM)-based coagulation management in cardiac surgery and major trauma. J Cardiothorac Vasc Anesth. 2012 Dec;26(6):1083-93. doi: 10.1053/j.jvca.2012.06.015. Epub 2012 Aug 3. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
