Knee Osteoarthritis — Clinical Evaluation of the Levitation Knee Brace
Citation(s)
Birtwhistle R, Morkem R, Peat G, Williamson T, Green ME, Khan S, Jordan KP Prevalence and management of osteoarthritis in primary care: an epidemiologic cohort study from the Canadian Primary Care Sentinel Surveillance Network. CMAJ Open. 2015 Jul 17;3(3):E270-5. doi: 10.9778/cmajo.20150018. eCollection 2015 Jul-Sep.
Bombardier C, Hawker GA, Mosher D The impact of arthritis in Canada: Today and over the next 30 years. Arthritis Alliance of Canda, 2011. https://www.arthritisalliance.ca/images/PDF/eng/Initiatives/20111022_2200_impact_of_arthritis.pdf
Cherian JJ, Bhave A, Kapadia BH, Starr R, McElroy MJ, Mont MA Strength and Functional Improvement Using Pneumatic Brace with Extension Assist for End-Stage Knee Osteoarthritis: A Prospective, Randomized trial. J Arthroplasty. 2015 May;30(5):747-53. doi: 10.1016/j.arth.2014.11.036. Epub 2014 Nov 29.
Felson DT The sources of pain in knee osteoarthritis. Curr Opin Rheumatol. 2005 Sep;17(5):624-8. doi: 10.1097/01.bor.0000172800.49120.97.
Heekin RD, Fokin AA Incidence of bicompartmental osteoarthritis in patients undergoing total and unicompartmental knee arthroplasty: is the time ripe for a less radical treatment? J Knee Surg. 2014 Feb;27(1):77-81. doi: 10.1055/s-0033-1349401. Epub 2013 Jul 19.
KELLGREN JH, LAWRENCE JS Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957 Dec;16(4):494-502. doi: 10.1136/ard.16.4.494. No abstract available.
McGibbon CA, Mohamed A Knee load reduction from an energy storing mechanical brace: a simulation study. 20th Biennial meeting, Canadian Society of Biomechanics, Halifax, Canada, Aug 2018.
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Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
