Avbersek A, Sisodiya S Does the primary literature provide support for clinical signs used to distinguish psychogenic nonepileptic seizures from epileptic seizures? J Neurol Neurosurg Psychiatry. 2010 Jul;81(7):719-25. doi: 10.1136/jnnp.2009.197996.
Benbadis SR, Allen Hauser W An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure. 2000 Jun;9(4):280-1. doi: 10.1053/seiz.2000.0409.
Brown RJ, Reuber M Towards an integrative theory of psychogenic non-epileptic seizures (PNES). Clin Psychol Rev. 2016 Jul;47:55-70. doi: 10.1016/j.cpr.2016.06.003. Epub 2016 Jun 17. No abstract available.
Cervenka MC, Patton K, Eloyan A, Henry B, Kossoff EH The impact of the modified Atkins diet on lipid profiles in adults with epilepsy. Nutr Neurosci. 2016;19(3):131-7. doi: 10.1179/1476830514Y.0000000162. Epub 2014 Nov 10.
Devinsky O, Gazzola D, LaFrance WC Jr Differentiating between nonepileptic and epileptic seizures. Nat Rev Neurol. 2011 Apr;7(4):210-20. doi: 10.1038/nrneurol.2011.24. Epub 2011 Mar 8.
Direk N, Kulaksizoglu IB, Alpay K, Gurses C Using personality disorders to distinguish between patients with psychogenic nonepileptic seizures and those with epileptic seizures. Epilepsy Behav. 2012 Feb;23(2):138-41. doi: 10.1016/j.yebeh.2011.11.013. Epub 2012 Jan 10.
Dixit R, Popescu A, Bagic A, Ghearing G, Hendrickson R Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring. Epilepsy Behav. 2013 Aug;28(2):137-40. doi: 10.1016/j.yebeh.2013.05.004. Epub 2013 Jun 5.
Duncan R, Oto M, Wainman-Lefley J Mortality in a cohort of patients with psychogenic non-epileptic seizures. J Neurol Neurosurg Psychiatry. 2012 Jul;83(7):761-2. doi: 10.1136/jnnp-2012-302900.
Duncan R, Oto M Predictors of antecedent factors in psychogenic nonepileptic attacks: multivariate analysis. Neurology. 2008 Sep 23;71(13):1000-5. doi: 10.1212/01.wnl.0000326593.50863.21.
Johnson E, Cervenka M Dietary therapy in adults: history, demand, and results. Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease: Oxford University Press, New York; 2017. p. 16-25.
Klein P, Janousek J, Barber A, Weissberger R Ketogenic diet treatment in adults with refractory epilepsy. Epilepsy Behav. 2010 Dec;19(4):575-9. doi: 10.1016/j.yebeh.2010.09.016.
Klein P, Tyrlikova I, Mathews GC Dietary treatment in adults with refractory epilepsy: a review. Neurology. 2014 Nov 18;83(21):1978-85. doi: 10.1212/WNL.0000000000001004. Epub 2014 Oct 29.
Kossoff EH, Cervenka MC, Henry BJ, Haney CA, Turner Z A decade of the modified Atkins diet (2003-2013): Results, insights, and future directions. Epilepsy Behav. 2013 Dec;29(3):437-42. doi: 10.1016/j.yebeh.2013.09.032.
Kossoff EH, Rowley H, Sinha SR, Vining EP A prospective study of the modified Atkins diet for intractable epilepsy in adults. Epilepsia. 2008 Feb;49(2):316-9. doi: 10.1111/j.1528-1167.2007.01256.x. Epub 2007 Oct 5.
Kverneland M, Selmer KK, Nakken KO, Iversen PO, Tauboll E A prospective study of the modified Atkins diet for adults with idiopathic generalized epilepsy. Epilepsy Behav. 2015 Dec;53:197-201. doi: 10.1016/j.yebeh.2015.10.021. Epub 2015 Nov 14.
LaFrance Jr W, Bjørnaes H Designing treatment plans based on etiology of psychogenic nonepileptic seizures. Gates and Rowan's nonepilepfic seizures. 2010:266-80.
LaFrance WC Jr, Baker GA, Duncan R, Goldstein LH, Reuber M Minimum requirements for the diagnosis of psychogenic nonepileptic seizures: a staged approach: a report from the International League Against Epilepsy Nonepileptic Seizures Task Force. Epilepsia. 2013 Nov;54(11):2005-18. doi: 10.1111/epi.12356. Epub 2013 Sep 20.
McNally MA, Hartman AL Ketone bodies in epilepsy. J Neurochem. 2012 Apr;121(1):28-35. doi: 10.1111/j.1471-4159.2012.07670.x. Epub 2012 Feb 7.
Mosek A, Natour H, Neufeld MY, Shiff Y, Vaisman N Ketogenic diet treatment in adults with refractory epilepsy: a prospective pilot study. Seizure. 2009 Jan;18(1):30-3. doi: 10.1016/j.seizure.2008.06.001. Epub 2008 Aug 3.
Myers L, Perrine K, Lancman M, Fleming M, Lancman M Psychological trauma in patients with psychogenic nonepileptic seizures: trauma characteristics and those who develop PTSD. Epilepsy Behav. 2013 Jul;28(1):121-6. doi: 10.1016/j.yebeh.2013.03.033. Epub 2013 May 23.
Neal EG, Cross JH Efficacy of dietary treatments for epilepsy. J Hum Nutr Diet. 2010 Apr;23(2):113-9. doi: 10.1111/j.1365-277X.2010.01043.x.
Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Cell. 2018 Jun 14;173(7):1728-1741.e13. doi: 10.1016/j.cell.2018.04.027. Epub 2018 May 24. Erratum In: Cell. 2018 Jul 12;174(2):497.
Oto M, Espie CA, Duncan R An exploratory randomized controlled trial of immediate versus delayed withdrawal of antiepileptic drugs in patients with psychogenic nonepileptic attacks (PNEAs). Epilepsia. 2010 Oct;51(10):1994-9. doi: 10.1111/j.1528-1167.2010.02696.x. Epub 2010 Aug 17.
Paoli A, Rubini A, Volek JS, Grimaldi KA Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr. 2013 Aug;67(8):789-96. doi: 10.1038/ejcn.2013.116. Epub 2013 Jun 26. Erratum In: Eur J Clin Nutr. 2014 May;68(5):641.
Payne NE, Cross JH, Sander JW, Sisodiya SM The ketogenic and related diets in adolescents and adults--a review. Epilepsia. 2011 Nov;52(11):1941-8. doi: 10.1111/j.1528-1167.2011.03287.x. Epub 2011 Oct 17.
Perez DL, LaFrance WC Jr Nonepileptic seizures: an updated review. CNS Spectr. 2016 Jun;21(3):239-46. doi: 10.1017/S109285291600002X. Epub 2016 Mar 21.
Pfeifer HH, Thiele EA Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy. Neurology. 2005 Dec 13;65(11):1810-2. doi: 10.1212/01.wnl.0000187071.24292.9e.
Reuber M, Brown RJ Understanding psychogenic nonepileptic seizures-Phenomenology, semiology and the Integrative Cognitive Model. Seizure. 2017 Jan;44:199-205. doi: 10.1016/j.seizure.2016.10.029. Epub 2016 Nov 15.
Rivera Espinoza Y Microbiota intestinal: su importancia en la salud y los factores que la modifican. Lat Am J Clin Sci Med Technol. 2020;2(2):185-96.
Selkirk M, Duncan R, Oto M, Pelosi A Clinical differences between patients with nonepileptic seizures who report antecedent sexual abuse and those who do not. Epilepsia. 2008 Aug;49(8):1446-50. doi: 10.1111/j.1528-1167.2008.01611.x. Epub 2008 Apr 10.
Sigurdardottir KR, Olafsson E Incidence of psychogenic seizures in adults: a population-based study in Iceland. Epilepsia. 1998 Jul;39(7):749-52. doi: 10.1111/j.1528-1157.1998.tb01161.x.
Smith M, Politzer N, Macgarvie D, McAndrews MP, Del Campo M Efficacy and tolerability of the modified Atkins diet in adults with pharmacoresistant epilepsy: a prospective observational study. Epilepsia. 2011 Apr;52(4):775-80. doi: 10.1111/j.1528-1167.2010.02941.x. Epub 2011 Jan 26.
Wikberg C, Pettersson A, Westman J, Bjorkelund C, Petersson EL Patients' perspectives on the use of the Montgomery-Asberg depression rating scale self-assessment version in primary care. Scand J Prim Health Care. 2016 Dec;34(4):434-442. doi: 10.1080/02813432.2016.1248635. Epub 2016 Nov 2.
Williams TJ, Cervenka MC The role for ketogenic diets in epilepsy and status epilepticus in adults. Clin Neurophysiol Pract. 2017 Jul 1;2:154-160. doi: 10.1016/j.cnp.2017.06.001. eCollection 2017.
Ye F, Li XJ, Jiang WL, Sun HB, Liu J Efficacy of and patient compliance with a ketogenic diet in adults with intractable epilepsy: a meta-analysis. J Clin Neurol. 2015 Jan;11(1):26-31. doi: 10.3988/jcn.2015.11.1.26. Epub 2015 Jan 2.
Zupec-Kania BA, Spellman E An overview of the ketogenic diet for pediatric epilepsy. Nutr Clin Pract. 2008 Dec-2009 Jan;23(6):589-96. doi: 10.1177/0884533608326138.
Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.