NCT01496846 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Brandt RG, Anderson PF, McDonald NJ, Sohn W, Peters MC
The pulpal anesthetic efficacy of articaine versus lidocaine in dentistry: a meta-analysis. J Am Dent Assoc. 2011 May;142(5):493-504.
Rogers BS, Botero TM, McDonald NJ, Gardner RJ, Peters MC
Efficacy of articaine versus lidocaine as a supplemental buccal infiltration in mandibular molars with irreversible pulpitis: a prospective, randomized, double-blind study. J Endod. 2014 Jun;40(6):
Rogers BS, McDonald NJ, Gardner R, Botero T, Shlafer M, Peters MC
Anesthetic Efficacy of Articaine vs Lidocaine as Supplemental Infiltration after Unsuccessful IANB of Irreversible Pulpitis Mandibular Molars. AAE Annual Meeting. Honolulu, Hawaii, April 2
Shapiro MR, McDonald NJ, Gardner RJ, Peters MC, Botero TM
Efficacy of Articaine versus Lidocaine In Supplemental Infiltration For Mandibular First versus Second Molars with Irreversible Pulpitis. J Endod, under review (Sep 2017).

Articaine Versus Lidocaine Supplemental Infiltration Efficacy in Irreversible Pulpitis Mandibular Molars After Failed Inferior Alveolar Nerve Block

Clinical trial NCT01496846 - References