NCT01248689 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

1) Artru, A
A. and Y. Momota, Trabecular outflow facility and formation rate of aqueous humor during anesthesia with sevoflurane-nitrous oxide or sevoflurane-remifentanil in rabbits. Anesth Analg, 1999. 88(4): p. 781-6. 2) Blumberg, D., et al., The effects of sevoflurane and ketamine on intraocular pressure in children during examination under anesthesia. Am J Ophthalmol, 2007. 143(3): p. 494-9. 3) Murphy, D.F., Anesthesia and intraocular pressure. Anesth Analg, 1985. 64(5): p. 520-30. 4) Sator, S., et al., Desflurane maintains intraocular pressure at an equivalent level to isoflurane and propofol during unstressed non-ophthalmic surgery. Br J Anaesth, 1998. 80(2): p. 243-4. 5) Sator-Katzenschlager, S., et al., Sevoflurane and propofol decrease intraocular pressure equally during non-ophthalmic surgery and recovery. Br J Anaesth, 2002. 89(5): p. 764-6. 6) Rosenbaum AL, S.A., Clinical Strabismus Management: Principles and Surgical Techniques. 1999, Philadelphia.

The Effect of Different Concentrations of Sevoflorane on Intraocular Pressure in Children Undergoing Ocular Surgery Under General Anesthesia

Clinical trial NCT01248689 - References