Intracranial Aneurysm — Medina Embolization Device In Neurovascular Aneurysm Study
Citation(s)
Abdihalim M, Watanabe M, Chaudhry SA, Jagadeesan B, Suri MF, Qureshi AI Are coil compaction and aneurysmal growth two distinct etiologies leading to recurrence following endovascular treatment of intracranial aneurysm? J Neuroimaging. 2014 Mar-Apr;24(2):171-5. doi: 10.1111/j.1552-6569.2012.00786.x. Epub 2013 Jan 14.
Crobeddu E, Lanzino G, Kallmes DF, Cloft HJ Review of 2 decades of aneurysm-recurrence literature, part 2: Managing recurrence after endovascular coiling. AJNR Am J Neuroradiol. 2013 Mar;34(3):481-5. doi: 10.3174/ajnr.A2958. Epub 2012 Mar 15. Review.
Gemmete JJ, Elias AE, Chaudhary N, Pandey AS Endovascular methods for the treatment of intracranial cerebral aneurysms. Neuroimaging Clin N Am. 2013 Nov;23(4):563-91. doi: 10.1016/j.nic.2013.03.007. Epub 2013 May 25. Review.
Im SH, Han MH, Kwon OK, Kwon BJ, Kim SH, Kim JE, Oh CW Endovascular coil embolization of 435 small asymptomatic unruptured intracranial aneurysms: procedural morbidity and patient outcome. AJNR Am J Neuroradiol. 2009 Jan;30(1):79-84. doi: 10.3174/ajnr.A1290. Epub 2008 Sep 3.
Inagawa T, Hirano A Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol. 1990 Dec;34(6):361-5.
Lanzino G, Murad MH, d'Urso PI, Rabinstein AA Coil embolization versus clipping for ruptured intracranial aneurysms: a meta-analysis of prospective controlled published studies. AJNR Am J Neuroradiol. 2013 Sep;34(9):1764-8. doi: 10.3174/ajnr.A3515. Epub 2013 Apr 11.
Miller TR, Jindal G, Krejza J, Gandhi D Impact of Endovascular Technique on Fluoroscopy Usage: Stent-Assisted Coiling versus Flow Diversion for Paraclinoid Internal Carotid Artery Aneurysms. Neuroradiol J. 2014 Dec;27(6):725-31. doi: 10.15274/NRJ-2014-10094. Epub 2014 Dec 1.
Mori K, Nakao Y, Horinaka N, Wada R, Hirano A, Maeda M Cerebral aneurysm regrowth and coil unraveling after incomplete Guglielmi detachable coil embolization: serial angiographical and histological findings. Neurol Med Chir (Tokyo). 2003 Jun;43(6):293-7.
Pierot L, Cognard C, Anxionnat R, Ricolfi F; CLARITY Investigators Endovascular treatment of ruptured intracranial aneurysms: factors affecting midterm quality anatomic results: analysis in a prospective, multicenter series of patients (CLARITY). AJNR Am J Neuroradiol. 2012 Sep;33(8):1475-80. Epub 2012 Apr 19.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
