Intergenerational Relations — Maternal Psychopathology and Offspring Mental Health (PSI_PER)
Citation(s)
Black DW, Gaffney GR, Schlosser S, Gabel J Children of parents with obsessive-compulsive disorder -- a 2-year follow-up study. Acta Psychiatr Scand. 2003 Apr;107(4):305-13.
Byatt N, Levin LL, Ziedonis D, Moore Simas TA, Allison J Enhancing Participation in Depression Care in Outpatient Perinatal Care Settings: A Systematic Review. Obstet Gynecol. 2015 Nov;126(5):1048-58. doi: 10.1097/AOG.0000000000001067. Review.
Challacombe F, Salkovskis P A preliminary investigation of the impact of maternal obsessive-compulsive disorder and panic disorder on parenting and children. J Anxiety Disord. 2009 Oct;23(7):848-57. doi: 10.1016/j.janxdis.2009.04.002. Epub 2009 Apr 23.
Goodman JH Postpartum depression beyond the early postpartum period. J Obstet Gynecol Neonatal Nurs. 2004 Jul-Aug;33(4):410-20. Review.
Guintivano J, Arad M, Gould TD, Payne JL, Kaminsky ZA Antenatal prediction of postpartum depression with blood DNA methylation biomarkers. Mol Psychiatry. 2014 May;19(5):560-7. doi: 10.1038/mp.2013.62. Epub 2013 May 21. Erratum in: Mol Psychiatry. 2014 May; 19(5):633.
Lindahl V, Pearson JL, Colpe L Prevalence of suicidality during pregnancy and the postpartum. Arch Womens Ment Health. 2005 Jun;8(2):77-87. Epub 2005 May 11. Review.
Low NC, Dugas E, Constantin E, Karp I, Rodriguez D, O'Loughlin J The association between parental history of diagnosed mood/anxiety disorders and psychiatric symptoms and disorders in young adult offspring. BMC Psychiatry. 2012 Nov 5;12:188. doi: 10.1186/1471-244X-12-188.
Martini J, Knappe S, Beesdo-Baum K, Lieb R, Wittchen HU Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Hum Dev. 2010 May;86(5):305-10. doi: 10.1016/j.earlhumdev.2010.04.004. Epub 2010 May 23.
Paulson JF, Bazemore SD Prenatal and postpartum depression in fathers and its association with maternal depression: a meta-analysis. JAMA. 2010 May 19;303(19):1961-9. doi: 10.1001/jama.2010.605.
Ruiz SK, Harris SJ, Martinez P, Gold PM, Klimes-Dougan B Young adult's attachment style as a partial mediator between maternal functioning and young adult offsprings' functioning. J Affect Disord. 2018 May;232:393-399. doi: 10.1016/j.jad.2017.12.034. Epub 2018 Jan 9.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
