Insulin Resistance — Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism
Citation(s)
Chubb SA, Davis WA, Davis TM Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the Fremantle diabetes study. J Clin Endocrinol Metab. 2005 Sep;90(9):5317-20. doi: 10.1210/jc.2005-0298. Epub 2005 Jun 28.
Mari A, Ahren B, Pacini G Assessment of insulin secretion in relation to insulin resistance. Curr Opin Clin Nutr Metab Care. 2005 Sep;8(5):529-33. doi: 10.1097/01.mco.0000171130.23441.59.
Sanghvi A, Virji MA, Warty V, Dimasi MJ Differential suppression of lymphocyte cholesterol synthesis by low density lipoprotein and erythrocyte insulin receptors in normolipidemic subjects. Atherosclerosis. 1983 Dec;49(3):307-18. doi: 10.1016/0021-9150(83)90141-7.
Singh BM, Goswami B, Mallika V Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital. Indian J Clin Biochem. 2010 Apr;25(2):141-5. doi: 10.1007/s12291-010-0026-x. Epub 2010 May 27.
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
