Anderson KF Antibacterial bacteriological swabs. Br Med J. 1965;2:1123-1124.
Bartzokas CA, Gibson MF, Graham R, Pinder DC A comparison of triclosan and chlorhexidine preparations with 60 per cent isopropyl alcohol for hygienic hand disinfection. J Hosp Infect. 1983 Sep;4(3):245-55.
Bedoux G, Roig B, Thomas O, Dupont V, Le Bot B Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environ Sci Pollut Res Int. 2012 May;19(4):1044-65. doi: 10.1007/s11356-011-0632-z. Epub 2011 Nov 5. Review.
D'Arezzo S, Lanini S, Puro V, Ippolito G, Visca P High-level tolerance to triclosan may play a role in Pseudomonas aeruginosa antibiotic resistance in immunocompromised hosts: evidence from outbreak investigation. BMC Res Notes. 2012 Jan 19;5:43. doi: 10.1186/1756-0500-5-43.
Edmiston CE Jr, Seabrook GR, Johnson CP, Paulson DS, Beausoleil CM Comparative of a new and innovative 2% chlorhexidine gluconate-impregnated cloth with 4% chlorhexidine gluconate as topical antiseptic for preparation of the skin prior to surgery. Am J Infect Control. 2007 Mar;35(2):89-96.
Eiselt D Presurgical skin preparation with a novel 2% chlorhexidine gluconate cloth reduces rates of surgical site infection in orthopaedic surgical patients. Orthop Nurs. 2009 May-Jun;28(3):141-5. doi: 10.1097/NOR.0b013e3181a469db.
Hibbard JS, Mulberry GK, Brady AR A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol, and 2% aqueous chlorhexidine. J Infus Nurs. 2002 Jul-Aug;25(4):244-9.
Hobson DW, Bolsen K Methods of testing oral and topical antiseptics and antimicrobials. In: Block SS, editor. Disinfection, Sterilization, and Preservation. 5th Ed, Philadelphia [PA]: Lippincott Williams & Wilkins; 2001. p.1329-1359.
Jones RD, Jampani HB, Newman JL, Lee AS Triclosan: a review of effectiveness and safety in health care settings. Am J Infect Control. 2000 Apr;28(2):184-96. Review.
Kampf G, Kramer A Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs. Clin Microbiol Rev. 2004 Oct;17(4):863-93, table of contents. Review.
Karpanen TJ, Worthington T, Hendry ER, Conway BR, Lambert PA Antimicrobial efficacy of chlorhexidine digluconate alone and in combination with eucalyptus oil, tea tree oil and thymol against planktonic and biofilm cultures of Staphylococcus epidermidis. J Antimicrob Chemother. 2008 Nov;62(5):1031-6. doi: 10.1093/jac/dkn325. Epub 2008 Aug 13.
Levy SB Antibacterial household products: cause for concern. Emerg Infect Dis. 2001;7(3 Suppl):512-5.
Macias JH, Arreguin V, Munoz JM, Alvarez JA, Mosqueda JL, Macias AE Chlorhexidine is a better antiseptic than povidone iodine and sodium hypochlorite because of its substantive effect. Am J Infect Control. 2013 Jul;41(7):634-7. doi: 10.1016/j.ajic.2012.10.002. Epub 2013 Feb 4.
Malhotra S, Dharmadasa A, Yentis SM One vs two applications of chlorhexidine/ethanol for disinfecting the skin: implications for regional anaesthesia. Anaesthesia. 2011 Jul;66(7):574-8. doi: 10.1111/j.1365-2044.2011.06706.x. Epub 2011 May 24.
McDonnell G, Russell AD Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. Review. Erratum in: Clin Microbiol Rev 2001 Jan;14(1):227.
Milstone AM, Passaretti CL, Perl TM Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis. 2008 Jan 15;46(2):274-81. doi: 10.1086/524736. Review.
Newman JL, Kaiser NE Extended activity of healthcare antiseptic products: Manivannan G. Disinfection and decontamination, Principles, applications and related issues. 1st Edition, St. Louis, Missouri, USA. CRC Press Editorial, 2007, Oct: 155-152
Russell AD Whither triclosan? J Antimicrob Chemother. 2004 May;53(5):693-5. Epub 2004 Apr 8. Review.
Small H, Adams D, Casey AL, Crosby CT, Lambert PA, Elliott T Efficacy of adding 2% (w/v) chlorhexidine gluconate to 70% (v/v) isopropyl alcohol for skin disinfection prior to peripheral venous cannulation. Infect Control Hosp Epidemiol. 2008 Oct;29(10):963-5. doi: 10.1086/590664.
Sogawa Y, Kobayashi H, Kajiura T, Nishihara Y Comparison of residual antimicrobial activity of chlorhexidine-containing antiseptics: An express report. J Healthc Infect 2010;2:32-36.
Swenson BR, Hedrick TL, Metzger R, Bonatti H, Pruett TL, Sawyer RG Effects of preoperative skin preparation on postoperative wound infection rates: a prospective study of 3 skin preparation protocols. Infect Control Hosp Epidemiol. 2009 Oct;30(10):964-71. doi: 10.1086/605926.
Tanner J Methods of skin antisepsis for preventing SSIs. Nurs Times. 2012 Sep 11-17;108(37):20, 22.
White WD Antibacterial bacteriological swab. Br Med J. 1965; 2:229-230.
Williamson P, Kligman AM A new method for the quantitative investigation of cutaneous bacteria. J Invest Dermatol. 1965 Dec;45(6):498-503.
Residual Effect of Chlorhexidine 2% / Isopropyl Alcohol 70% Compared to Triclosan 1% / Isopropyl Alcohol 70%
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
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Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.