Immunosuppression — Microfluidics and Transcriptomics in Post Solid Organ Transplant Patients
Citation(s)
Antoniades CG, Berry PA, Wendon JA, Vergani D The importance of immune dysfunction in determining outcome in acute liver failure. J Hepatol. 2008 Nov;49(5):845-61. doi: 10.1016/j.jhep.2008.08.009. Epub 2008 Aug 21. Review.
Benítez C, Lozano JJ, Fueyo AS Gene expression profiling and transplantation tolerance in the clinic. Transplantation. 2009 Aug 15;88(3 Suppl):S50-3. doi: 10.1097/TP.0b013e3181af7d17. Review.
Huskey J, Gralla J, Wiseman AC Single time point immune function assay (ImmuKnow) testing does not aid in the prediction of future opportunistic infections or acute rejection. Clin J Am Soc Nephrol. 2011 Feb;6(2):423-9. doi: 10.2215/CJN.04210510. Epub 2010 Nov 18.
Kim S, Park YM Specific gene expression patterns in liver cirrhosis. Biochem Biophys Res Commun. 2005 Aug 26;334(2):681-8.
Larson AM Palliative care for patients with end-stage liver disease. Curr Gastroenterol Rep. 2015 May;17(5):440. doi: 10.1007/s11894-015-0440-6. Review.
Luo Y, Shi B, Qian Y, Bai H, Chang J Sequential monitoring of TIM-3 gene expression in peripheral blood for diagnostic and prognostic evaluation of acute rejection in renal graft recipients. Transplant Proc. 2011 Dec;43(10):3669-74. doi: 10.1016/j.transproceed.2011.08.106.
Mas VR, Fassnacht R, Archer KJ, Maluf D Molecular mechanisms involved in the interaction effects of alcohol and hepatitis C virus in liver cirrhosis. Mol Med. 2010 Jul-Aug;16(7-8):287-97. doi: 10.2119/molmed.2009.00165. Epub 2010 Mar 26.
Mathias B, Lipori G, Moldawer LL, Efron PA Integrating "big data" into surgical practice. Surgery. 2016 Feb;159(2):371-4. doi: 10.1016/j.surg.2015.08.043. Epub 2015 Oct 23. Review.
Menon MC, Keung KL, Murphy B, O'Connell PJ The Use of Genomics and Pathway Analysis in Our Understanding and Prediction of Clinical Renal Transplant Injury. Transplantation. 2016 Jul;100(7):1405-14. doi: 10.1097/TP.0000000000000943. Review.
Reeve J, Halloran PF, Kaplan B Common errors in the implementation and interpretation of microarray studies. Transplantation. 2015 Mar;99(3):470-5. doi: 10.1097/TP.0000000000000691.
Sood S, Testro AG Immune monitoring post liver transplant. World J Transplant. 2014 Mar 24;4(1):30-9. doi: 10.5500/wjt.v4.i1.30. Review.
Sui W, Dai Y, Huang Y, Lan H, Yan Q, Huang H Microarray analysis of MicroRNA expression in acute rejection after renal transplantation. Transpl Immunol. 2008 Apr;19(1):81-5. doi: 10.1016/j.trim.2008.01.007. Epub 2008 Feb 5.
Sui W, Lin H, Peng W, Huang Y, Chen J, Zhang Y, Dai Y Molecular dysfunctions in acute rejection after renal transplantation revealed by integrated analysis of transcription factor, microRNA and long noncoding RNA. Genomics. 2013 Oct;102(4):310-22. doi: 10.1016/j.ygeno.2013.05.002. Epub 2013 May 15.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.