Caron M, Hoa S, Hudson M, Schwartzman K, Steele R Pulmonary function tests as outcomes for systemic sclerosis interstitial lung disease. Eur Respir Rev. 2018 May 15;27(148). pii: 170102. doi: 10.1183/16000617.0102-2017. Print 2018 Jun 30. Review.
Dale MT, McKeough ZJ, Munoz PA, Corte P, Bye PT, Alison JA Physical activity in people with asbestos related pleural disease and dust-related interstitial lung disease: An observational study. Chron Respir Dis. 2015 Nov;12(4):291-8. doi: 10.1177/1479972315587518. Epub 2015 Jun 5.
Dale MT, McKeough ZJ, Troosters T, Bye P, Alison JA Exercise training to improve exercise capacity and quality of life in people with non-malignant dust-related respiratory diseases. Cochrane Database Syst Rev. 2015 Nov 5;(11):CD009385. doi: 10.1002/14651858.CD009385.pub2. Review.
Deniz S, Sahin H, Yalniz E Does the severity of interstitial lung disease affect the gains from pulmonary rehabilitation? Clin Respir J. 2018 Jun;12(6):2141-2150. doi: 10.1111/crj.12785. Epub 2018 Mar 24.
Dowman L, Hill CJ, Holland AE Pulmonary rehabilitation for interstitial lung disease. Cochrane Database Syst Rev. 2014 Oct 6;(10):CD006322. doi: 10.1002/14651858.CD006322.pub3. Review.
Gloeckl R, Heinzelmann I, Kenn K Whole body vibration training in patients with COPD: A systematic review. Chron Respir Dis. 2015 Aug;12(3):212-21. doi: 10.1177/1479972315583049. Epub 2015 Apr 22. Review.
Janaudis-Ferreira T Exercise training improves exercise capacity and quality of life in people with interstitial lung disease [synopsis]. J Physiother. 2017 Oct;63(4):257. doi: 10.1016/j.jphys.2017.07.002. Epub 2017 Sep 6.
Ramadurai D, Riordan M, Graney B, Churney T, Olson AL, Swigris JJ The impact of carrying supplemental oxygen on exercise capacity and dyspnea in patients with interstitial lung disease. Respir Med. 2018 May;138:32-37. doi: 10.1016/j.rmed.2018.03.025. Epub 2018 Mar 26.
Wickerson L, Mathur S, Helm D, Singer L, Brooks D Physical activity profile of lung transplant candidates with interstitial lung disease. J Cardiopulm Rehabil Prev. 2013 Mar-Apr;33(2):106-12. doi: 10.1097/HCR.0b013e3182839293.
Wickerson L Exercise training improves exercise capacity and quality of life in people with interstitial lung disease [commentary]. J Physiother. 2017 Oct;63(4):257. doi: 10.1016/j.jphys.2017.07.001. Epub 2017 Sep 6.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
