Hypothyroidism — Early Detection of Endolymphatic Hydrops in Hypothyroid Patients
Citation(s)
1 Elmoazen DM, Sobhy OA, Abd Elbaky F. Vestibular evoked myogenic potentials and video head impulse tests in different stages of Meniere's disease. Advanced Arab Academy of Audio-Vestibulogy Journal. 2015;2(2):45. 2. Baloh R, Honrubia V. Endolymphatic hydrops (Meniere's syndrome). Clinical neurophysiology of the vestibular system, 3rd ed. New York: Oxford …; 2001. 3. Friedman RA, Ryan AF. The molecular mechanism and genetics of Meniere disease. Meniere's disease: Kugler Pubblications The Hague; 1999. p. 356-69. 4. Yoo T, Ge X, Sener O, Mora M, Kwon SS, Mora F, et al. Presence of autoantibodies in the sera of Meniere's disease. Annals of Otology, Rhinology & Laryngology. 2001;110(5):425-9. 5. Fisher LM, Derebery MJ, Friedman RA. Oral steroid treatment for hearing improvement in Ménière's disease and endolymphatic hydrops. Otology & Neurotology. 2012;33(9):1685-91. 6. Hsu L, Zhu X-N, Zhao Y-S. Immunoglobulin E and circulating immune complexes in endolymphatic hydrops. Annals of Otology, Rhinology & Laryngology. 1990;99(7):535-8. 7. Garcia-Purrinos F, Ferri E, Rosell A, Calvo J. Combined intratympanic and intravenous dexomethasone to control vertigo in Meniere disease. Acta otorrinolaringologica espanola. 2005;56(2):74-7. 8. Shea JJ. Autoimmune sensorineural hearing loss as an aggravating factor in Meniere's disease. Neurophysiological and Clinical Aspects of Vestibular Disorders. 30: Karger Publishers; 1983. p. 254-7. 9. Xenellis J, Morrison A, McClowskey D, Festenstein H. HLA antigens in the pathogenesis of Meniere's disease. The Journal of Laryngology & Otology. 1986;100(1):21-4. 10. Duntas LH, Mantzou E, Koutras DA. Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism. Thyroid. 2002;12(11):1003-7. 11. Goebel JA. 2015 Equilibrium Committee amendment to the 1995 AAO-HNS guidelines for the definition of Meniere's disease. Otolaryngology--Head and Neck Surgery. 2016;154(3):403-4. 12. Kim C-H, Shin JE, Yoo MH, Park HJ. Direction-changing and direction-fixed positional nystagmus in patients with vestibular neuritis and meniere disease. Clinical and Experimental Otorhinolaryngology. 2019;12(3):255. 13. Alexander TH, Harris JP. Current epidemiology of Meniere's syndrome. Otolaryngologic Clinics of North America. 2010;43(5):965-70. 14. Shambaugh Jr GE. Endocrine aspects of meniere's disease. The Laryngoscope. 1959;69(8):1027-32. 15. Powers WH. Metabolic aspects of Meniere's disease. The Laryngoscope. 1978;88(1):122-9. 16. Kinney SE. The metabolic evaluation in Meniere's disease. Otolaryngology-Head and Neck Surgery. 1980;88(5):594-8. 17. Meyerhoff WL, Paparella MM, Gudbrandsson FK. Clinical evaluation of Meniere's disease. The Laryngoscope. 1981;91(10):1663-8. 18. Evans K, Baldwin D, Bainbridge D, Morrison A. Immune status in patients with Meniere's disease. Archives of oto-rhino-laryngology. 1988;245(5):287-92. 19. Seo T, Node M, Yukimasa A, Sakagami M. Furosemide loading vestibular evoked myogenic potential for unilateral Ménière's disease. Otology & neurotology. 2003;24(2):283-8. 20. Colebatch J, Halmagyi G. Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology. 1992;42(8):1635-. 21. Halmagyi G, Colebatch J, Curthoys I. New tests of vestibular function. Bailliere's clinical neurology. 1994;3(3):485-500. 22. Jacobson G. mccaslin DL. The Vestibular-Evoked Myogenic Potential and Other Sonomotor Evoked Potentials. Auditory Evoked Potentials Basic Principles and Clinical Application. USA Lippincott Williams & Wilkins. 2007;8(27):572-98. 23. Jacobson G, McCaslin D. The vestibular evoked myogenic potential and other sonomotor evoked potentials. Lippincott Williams & Wilkins Baltimore, Md, USA; 2007. p. 572-98.
Early Detection of Endolymphatic Hydrops in Hypothyroid Patients
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
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Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
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Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.