Clinical trial NCT00421200 - References

Hypotension — Phase III Study of Hemospan® to Prevent Hypotension in Hip Arthroplasty

Citation(s)

•   Björkholm M, Fagrell B, Przybelski R, Winslow N, Young M, Winslow RM
  A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol. Haematologica. 2005 Apr;90(4):505-15.
•   Cabrales P, Tsai AG, Winslow RM, Intaglietta M
  Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2146-53. Epub 2005 Jan 6.
•   Olofsson C, Ahl T, Johansson T, Larsson S, Nellgård P, Ponzer S, Fagrell B, Przybelski R, Keipert P, Winslow N, Winslow RM
  A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified Hemoglobin (Hemospan) in patients undergoing major orthopedic surgery. Anesthesiology. 2006 Dec;105(6):1153-63.
•   Olofsson CI, Górecki AZ, Dirksen R, Kofranek I, Majewski JA, Mazurkiewicz T, Jahoda D, Fagrell B, Keipert PE, Hardiman YJ, Levy H; Study 6084 Clinical Investigators
  Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing pr
•   Tsai AG, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M
  Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood. 2006 Nov 15;108(10):3603-10. Epub 2006 Jul 20.
•   Winslow RM
  Current status of oxygen carriers ('blood substitutes'): 2006. Vox Sang. 2006 Aug;91(2):102-10. Review.
•   Winslow RM
  Red cell substitutes. Semin Hematol. 2007 Jan;44(1):51-9. Review.
•   Young MA, Riddez L, Kjellström BT, Bursell J, Winslow F, Lohman J, Winslow RM
  MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Crit Care Med. 2005 Aug;33(8):1794-804.

A Randomized, Double-blind, Phase III Study of the Efficacy and Safety of an Oxygen-carrying Plasma Expander, Hemospan®, Compared With Voluven® to Prevent Hypotension in Patients Undergoing Primary Hip Arthroplasty With Spinal Anesthesia

Details for clinical trial NCT00421200