Hypertrophy — Resistance Training Effects on Muscle Morphological, Mechanical and Contractile Properties
Citation(s)
Davies TB, Kuang K, Orr R, Halaki M, Hackett D Effect of Movement Velocity During Resistance Training on Dynamic Muscular Strength: A Systematic Review and Meta-Analysis. Sports Med. 2017 Aug;47(8):1603-1617. doi: 10.1007/s40279-017-0676-4. Review.
Hackett DA, Davies TB, Orr R, Kuang K, Halaki M Effect of movement velocity during resistance training on muscle-specific hypertrophy: A systematic review. Eur J Sport Sci. 2018 May;18(4):473-482. doi: 10.1080/17461391.2018.1434563. Epub 2018 Feb 12. Review.
Pryor RR, Sforzo GA, King DL Optimizing power output by varying repetition tempo. J Strength Cond Res. 2011 Nov;25(11):3029-34. doi: 10.1519/JSC.0b013e31820f50cb.
Schoenfeld BJ The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res. 2010 Oct;24(10):2857-72. doi: 10.1519/JSC.0b013e3181e840f3. Review.
The Effects of Resistance Training on Skeletal Muscle Morphological, Mechanical and Contractile Properties
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.